Generic competition · all medicines · read 12 November 2026
Which brand medicines have no generic listed as marketed?
1,062 brand medicine forms in the FDA Orange Book have no generic listed as marketed, and 772 of them still have a patent or exclusivity listed. The table orders them by the date the last listed protection ends. A listed date is the application holder's listing, not a launch date and not a ruling.
Compiled and checked by Vincent Wesley Couey (ORCID 0009-0005-6869-308X) from the Orange Book data files, downloaded 12 November 2026.
What are the brands with no generic listed?
| Ingredient | Form | Brand | Approved | Last listed protection ends |
|---|---|---|---|---|
| Pasireotide Diaspartate | Solution, Subcutaneous | Signifor | 2012 | 14 December 2026 |
| Brilliant Blue G | Solution, Ophthalmic | Tissueblue | 2019 | 20 December 2026 |
| Telavancin Hydrochloride | Powder, Intravenous | Vibativ | 2009 | 1 January 2027 |
| Olodaterol Hydrochloride | Spray, Metered, Inhalation | Striverdi Respimat | 2014 | 19 January 2027 |
| Chlorpheniramine Maleate; Ibuprofen; Pseudoephedrine Hydrochloride | Tablet, Oral | Advil Allergy Sinus | 2002 | 28 February 2027 |
| Bazedoxifene Acetate; Estrogens, Conjugated | Tablet, Oral | Duavee | 2013 | 10 March 2027 |
| Olive Oil; Soybean Oil | Emulsion, Intravenous | Clinolipid 20% | 2013 | 24 April 2027 |
| Chlorhexidine Gluconate; Isopropyl Alcohol | Sponge, Topical | Chloraprep One-Step, Chloraprep One-Step Frepp, Chloraprep With Tint | 2000 | 25 April 2027 |
| Florbetapir F-18 | Solution, Intravenous | Amyvid | 2012 | 30 April 2027 |
| Peramivir | Solution, Intravenous | Rapivab | 2014 | 7 May 2027 |
| Testosterone Undecanoate | Injectable, Intramuscular | Aveed | 2014 | 8 May 2027 |
| Darunavir | Suspension, Oral | Prezista | 2011 | 26 June 2027 |
| Nifurtimox | Tablet, Oral | Lampit | 2020 | 6 August 2027 |
| Uridine Triacetate | Granule, Oral | Vistogard, Xuriden | 2015 | 17 August 2027 |
| Chlorhexidine Gluconate | Cloth, Topical | Chlorhexidine Gluconate, Readyprep Chg | 2005 | 2 October 2027 |
| Belinostat | Powder, Intravenous | Beleodaq | 2014 | 27 October 2027 |
| Mannitol | Powder, Inhalation | Aridol Kit, Bronchitol | 2010 | 30 October 2027 |
| Umeclidinium Bromide | Powder, Inhalation | Incruse Ellipta | 2014 | 18 December 2027 |
| Midazolam | Spray, Nasal | Nayzilam | 2019 | 18 January 2028 |
| Istradefylline | Tablet, Oral | Nourianz | 2019 | 28 January 2028 |
| Dienogest; Estradiol Valerate | Tablet, Oral | Natazia | 2010 | 30 January 2028 |
| Ciclesonide | Aerosol, Metered, Inhalation | Alvesco | 2008 | 1 February 2028 |
| Ciclesonide | Spray, Metered, Nasal | Omnaris | 2006 | 1 February 2028 |
| Apomorphine Hydrochloride | Solution, Subcutaneous | Onapgo | 2025 | 3 February 2028 |
| Vorinostat | Capsule, Oral | Zolinza | 2006 | 18 March 2028 |
| Edoxaban Tosylate | Tablet, Oral | Savaysa | 2015 | 28 March 2028 |
| Miconazole Nitrate; White Petrolatum; Zinc Oxide | Ointment, Topical | Vusion | 2006 | 30 March 2028 |
| Clozapine | Suspension, Oral | Versacloz | 2013 | 1 May 2028 |
| Calcipotriene | Aerosol, Foam, Topical | Sorilux | 2010 | 7 May 2028 |
| Albumin Human | Injectable, Injection | Optison | 1997 | 9 May 2028 |
| Venlafaxine Besylate | Tablet, Extended Release, Oral | Venlafaxine Besylate | 2022 | 16 May 2028 |
| Pasireotide Pamoate | For Suspension, Intramuscular | Signifor Lar Kit | 2014 | 23 May 2028 |
| Quazepam | Tablet, Oral | Doral | 1985 | 3 June 2028 |
| Golodirsen | Solution, Intravenous | Vyondys 53 | 2019 | 28 June 2028 |
| Trabectedin | Powder, Intravenous | Yondelis | 2015 | 7 July 2028 |
| Ospemifene | Tablet, Oral | Osphena | 2013 | 9 July 2028 |
| Fexinidazole | Tablet, Oral | Fexinidazole | 2021 | 16 July 2028 |
| Tacrolimus | For Suspension, Oral | Prograf | 2018 | 16 July 2028 |
| Vandetanib | Tablet, Oral | Caprelsa | 2011 | 8 August 2028 |
| Ethinyl Estradiol; Levonorgestrel | System, Transdermal | Twirla | 2020 | 26 August 2028 |
| Tacrolimus | Tablet, Extended Release, Oral | Envarsus Xr | 2015 | 30 August 2028 |
| Olodaterol Hydrochloride; Tiotropium Bromide | Spray, Metered, Inhalation | Stiolto Respimat | 2015 | 13 September 2028 |
| Flutemetamol F-18 | Injectable, Intravenous | Vizamyl | 2013 | 16 September 2028 |
| Fluticasone Furoate | Spray, Metered, Nasal | Flonase Sensimist Allergy Relief | 2016 | 15 October 2028 |
| Riboflavin 5'-Phosphate Sodium | Solution/Drops, Ophthalmic | Epioxa Hd/Epioxa Kit, Photrexa Viscous In Dextran 20%/Photrexa | 2016 | 17 October 2028 |
| Fluocinolone Acetonide | Implant, Intravitreal | Iluvien | 2005 | 7 November 2028 |
| Lidocaine | System, Topical | Bondlido | 2025 | 10 November 2028 |
| Flibanserin | Tablet, Oral | Addyi | 2015 | 13 December 2028 |
| Vismodegib | Capsule, Oral | Erivedge | 2012 | 15 December 2028 |
| Posaconazole | For Suspension, Delayed Release, Oral | Noxafil Powdermix Kit | 2021 | 27 January 2029 |
| Technetium Tc-99m Tilmanocept | Injectable, Injection | Lymphoseek Kit | 2013 | 30 January 2029 |
| Azelaic Acid | Aerosol, Foam, Topical | Finacea | 2015 | 28 February 2029 |
| Aclidinium Bromide | Powder, Metered, Inhalation | Tudorza Pressair | 2012 | 13 March 2029 |
| Trazodone Hydrochloride | Solution, Oral | Raldesy | 2024 | 13 March 2029 |
| Bedaquiline Fumarate | Tablet, Oral | Sirturo | 2012 | 19 March 2029 |
| Ruxolitinib Phosphate | Tablet, Oral | Jakafi | 2011 | 22 March 2029 |
| Tapentadol Hydrochloride | Tablet, Extended Release, Oral | Nucynta Er | 2011 | 22 March 2029 |
| Carbinoxamine Maleate | Suspension, Extended Release, Oral | Karbinal Er | 2013 | 29 March 2029 |
| Fosdenopterin Hydrobromide | Powder, Intravenous | Nulibry | 2021 | 9 April 2029 |
| Mitomycin | For Solution, Topical | Mitosol | 2012 | 21 May 2029 |
| Alogliptin Benzoate; Metformin Hydrochloride | Tablet, Oral | Kazano | 2013 | 24 May 2029 |
| Methotrexate | Solution, Subcutaneous | Rasuvo | 2013 | 1 June 2029 |
| Alogliptin Benzoate; Pioglitazone Hydrochloride | Tablet, Oral | Oseni | 2013 | 4 June 2029 |
| Gabapentin Enacarbil | Tablet, Extended Release, Oral | Horizant | 2011 | 10 June 2029 |
| Alogliptin Benzoate | Tablet, Oral | Nesina | 2013 | 16 June 2029 |
| Triptorelin Pamoate | Injectable, Intramuscular | Trelstar | 2000 | 30 June 2029 |
| Triptorelin Pamoate | For Suspension, Extended Release, Intramuscular | Triptodur Kit | 2017 | 30 June 2029 |
| Mechlorethamine Hydrochloride | Gel, Topical | Valchlor | 2013 | 8 July 2029 |
| Fostemsavir Tromethamine | Tablet, Extended Release, Oral | Rukobia | 2020 | 13 July 2029 |
| Stiripentol | Capsule, Oral | Diacomit | 2018 | 14 July 2029 |
| Stiripentol | For Suspension, Oral | Diacomit | 2018 | 14 July 2029 |
| Acetaminophen; Naproxen Sodium | Tablet, Oral | Tylenol With Naproxen | 2026 | 24 July 2029 |
| Lonafarnib | Capsule, Oral | Zokinvy | 2020 | 26 July 2029 |
| Ethinyl Estradiol; Norelgestromin | System, Transdermal | Gwyn Lo | 2026 | 28 July 2029 |
| Canagliflozin; Metformin Hydrochloride | Tablet, Extended Release, Oral | Invokamet Xr | 2016 | 26 August 2029 |
| Raltegravir Potassium | Powder, Oral | Isentress | 2013 | 11 September 2029 |
| Rolapitant Hydrochloride | Tablet, Oral | Varubi | 2015 | 9 October 2029 |
| Naltrexone | For Suspension, Extended Release, Intramuscular | Vivitrol | 2006 | 15 October 2029 |
| Deferiprone | Solution, Oral | Ferriprox | 2015 | 26 October 2029 |
| Crizotinib | Capsule, Pellets, Oral | Xalkori | 2023 | 6 November 2029 |
| Crizotinib | Capsule, Oral | Xalkori | 2011 | 6 November 2029 |
| Ixazomib Citrate | Capsule, Oral | Ninlaro | 2015 | 20 November 2029 |
| Iomeprol | Solution, Intra-Arterial | Iomervu | 2024 | 27 November 2029 |
| Iomeprol | Solution, Intravenous | Iomervu | 2024 | 27 November 2029 |
| Lurbinectedin | Powder, Intravenous | Zepzelca | 2020 | 13 December 2029 |
| Triamcinolone Acetonide | Injectable, Intravitreal | Triesence | 2007 | 17 December 2029 |
| Menthol; Methyl Salicylate | Patch, Topical | Salonpas | 2008 | 3 January 2030 |
| Ivacaftor | Tablet, Oral | Kalydeco | 2012 | 13 February 2030 |
| Simvastatin | Suspension, Oral | Flolipid | 2016 | 23 February 2030 |
| Tazarotene | Aerosol, Foam, Topical | Fabior | 2012 | 24 February 2030 |
| Cetirizine Hydrochloride | Solution, Intravenous | Quzyttir | 2019 | 28 February 2030 |
| Technetium Tc-99m Tetrofosmin Kit | Injectable, Injection | Myoview, Myoview 30ml | 1996 | 10 March 2030 |
| Cariprazine Hydrochloride | Capsule, Oral | Vraylar | 2015 | 17 March 2030 |
| Tepotinib Hydrochloride | Tablet, Oral | Tepmetko | 2021 | 19 March 2030 |
| Ciprofloxacin Hydrochloride; Fluocinolone Acetonide | Solution/Drops, Otic | Otovel | 2016 | 24 March 2030 |
| Pacritinib Citrate | Capsule, Oral | Vonjo | 2022 | 25 March 2030 |
| Capsaicin | Patch, Topical | Qutenza | 2009 | 26 March 2030 |
| Oxycodone Hydrochloride | Tablet, Extended Release, Oral | Oxycontin | 1998 | 29 March 2030 |
| Oxymetazoline Hydrochloride; Tetracaine Hydrochloride | Spray, Metered, Nasal | Kovanaze | 2016 | 2 April 2030 |
| Albuterol Sulfate; Budesonide | Aerosol, Metered, Inhalation | Airsupra | 2023 | 28 May 2030 |
| Budesonide; Formoterol Fumarate | Aerosol, Metered, Inhalation | Symbicort Aerosphere | 2023 | 28 May 2030 |
| Raltegravir Potassium | Tablet, Chewable, Oral | Isentress | 2011 | 2 June 2030 |
| Azacitidine | Tablet, Oral | Onureg | 2020 | 3 June 2030 |
| Abacavir Sulfate; Dolutegravir Sodium; Lamivudine | Tablet, For Suspension, Oral | Triumeq Pd | 2022 | 8 June 2030 |
| Abacavir Sulfate; Dolutegravir Sodium; Lamivudine | Tablet, Oral | Triumeq | 2014 | 8 June 2030 |
| Dolutegravir Sodium | Tablet, Oral | Tivicay | 2013 | 8 June 2030 |
| Dolutegravir Sodium | Tablet, For Suspension, Oral | Tivicay Pd | 2020 | 8 June 2030 |
| Canagliflozin; Metformin Hydrochloride | Tablet, Oral | Invokamet | 2014 | 6 July 2030 |
| Etonogestrel | Implant, Implantation | Nexplanon | 2006 | 28 July 2030 |
| Gepirone Hydrochloride | Tablet, Extended Release, Oral | Exxua | 2023 | 2 September 2030 |
| Sotagliflozin | Tablet, Oral | Inpefa | 2023 | 7 October 2030 |
| Entrectinib | Pellets, Oral | Rozlytrek | 2023 | 20 October 2030 |
| Brimonidine Tartrate; Brinzolamide | Suspension/Drops, Ophthalmic | Simbrinza | 2013 | 30 October 2030 |
| Tobramycin | Powder, Inhalation | Tobi Podhaler | 2013 | 4 November 2030 |
| Casimersen | Solution, Intravenous | Amondys 45 | 2021 | 12 November 2030 |
| Umeclidinium Bromide; Vilanterol Trifenatate | Powder, Inhalation | Anoro Ellipta | 2013 | 29 November 2030 |
| Lanthanum Carbonate | Powder, Oral | Fosrenol | 2014 | 1 December 2030 |
| Methylnaltrexone Bromide | Solution, Subcutaneous | Relistor | 2008 | 31 December 2030 |
| Tedizolid Phosphate | Powder, Intravenous | Sivextro | 2014 | 31 December 2030 |
| Tedizolid Phosphate | Tablet, Oral | Sivextro | 2014 | 31 December 2030 |
| Besifloxacin Hydrochloride | Suspension/Drops, Ophthalmic | Besivance | 2009 | 9 January 2031 |
| Lidocaine; Tetracaine | Cream, Topical | Pliaglis | 2006 | 14 January 2031 |
| Pitavastatin Magnesium | Tablet, Oral | Zypitamag | 2017 | 19 January 2031 |
| Mitomycin | Powder, Pyelocalyceal | Jelmyto | 2020 | 20 January 2031 |
| Dolutegravir Sodium; Lamivudine | Tablet, Oral | Dovato | 2019 | 24 January 2031 |
| Selexipag | Powder, Intravenous | Uptravi | 2021 | 1 February 2031 |
| Cabotegravir Sodium | Tablet, Oral | Vocabria | 2021 | 4 February 2031 |
| Leuprolide Acetate | Powder, Intramuscular | Lupron Depot-Ped Kit | 1993 | 5 February 2031 |
| Leuprolide Acetate | Injectable, Injection | Lupron Depot | 1989 | 5 February 2031 |
| Travoprost | Implant, Intracameral | Idose Tr | 2023 | 14 February 2031 |
| Technetium Tc-99m Labeled Carbon | Aerosol, Inhalation | Technegas Kit | 2023 | 24 February 2031 |
| Telotristat Etiprate | Tablet, Oral | Xermelo | 2017 | 28 February 2031 |
| Methylnaltrexone Bromide | Tablet, Oral | Relistor | 2016 | 10 March 2031 |
| Formoterol Fumarate; Glycopyrrolate | Aerosol, Metered, Inhalation | Bevespi Aerosphere | 2016 | 17 March 2031 |
| Prasterone | Insert, Vaginal | Intrarosa | 2016 | 19 March 2031 |
| Fluticasone Furoate; Umeclidinium Bromide; Vilanterol Trifenatate | Powder, Inhalation | Trelegy Ellipta | 2017 | 11 April 2031 |
| Fluticasone Furoate; Vilanterol Trifenatate | Powder, Inhalation | Breo Ellipta | 2013 | 11 April 2031 |
| Trametinib Dimethyl Sulfoxide | Solution, Oral | Mekinist | 2023 | 15 April 2031 |
| Tiotropium Bromide | Spray, Metered, Inhalation | Spiriva Respimat | 2014 | 16 April 2031 |
| Isavuconazonium Sulfate | Capsule, Oral | Cresemba | 2015 | 8 June 2031 |
| Isavuconazonium Sulfate | Powder, Intravenous | Cresemba | 2015 | 8 June 2031 |
| Ivacaftor; Lumacaftor | Granule, Oral | Orkambi | 2018 | 11 June 2031 |
| Ivacaftor; Lumacaftor | Tablet, Oral | Orkambi | 2015 | 11 June 2031 |
| Sofosbuvir | Tablet, Oral | Sovaldi | 2013 | 11 June 2031 |
| Sofosbuvir | Pellets, Oral | Sovaldi | 2019 | 11 June 2031 |
| Delafloxacin Meglumine | Tablet, Oral | Baxdela | 2017 | 19 June 2031 |
| Drospirenone | Tablet, Oral | Slynd | 2019 | 28 June 2031 |
| Dronedarone Hydrochloride | Tablet, Oral | Multaq | 2009 | 30 June 2031 |
| Gedatolisib | Powder, Intravenous | Revtorpyk | 2026 | 14 July 2031 |
| Neratinib Maleate | Tablet, Oral | Nerlynx | 2017 | 18 July 2031 |
| Triamcinolone Acetonide | For Suspension, Extended Release, Intra-Articular | Zilretta | 2017 | 4 August 2031 |
| Econazole Nitrate | Aerosol, Foam, Topical | Ecoza | 2013 | 8 August 2031 |
| Treprostinil Diolamine | Tablet, Extended Release, Oral | Orenitram | 2013 | 11 August 2031 |
| Pretomanid | Tablet, Oral | Pretomanid | 2019 | 14 August 2031 |
| Apixaban | Tablet, For Suspension, Oral | Eliquis | 2025 | 24 August 2031 |
| Clascoterone | Cream, Topical | Winlevi | 2020 | 26 August 2031 |
| Letermovir | Pellets, Oral | Prevymis | 2024 | 30 August 2031 |
| Letermovir | Tablet, Oral | Prevymis | 2017 | 30 August 2031 |
| Tecovirimat | Solution, Intravenous | Tpoxx | 2022 | 4 September 2031 |
| Clonidine | Tablet, Extended Release, Oral | Nexiclon Xr | 2009 | 8 September 2031 |
| Floretyrosine F-18 | Solution, Intravenous | Pixclara | 2026 | 11 September 2031 |
| Cabotegravir | Suspension, Extended Release, Intramuscular | Apretude | 2021 | 15 September 2031 |
| Delgocitinib | Cream, Topical | Anzupgo | 2025 | 19 September 2031 |
| Macitentan; Tadalafil | Tablet, Oral | Opsynvi | 2024 | 22 September 2031 |
| Abemaciclib | Tablet, Oral | Verzenio | 2017 | 28 September 2031 |
| Lusutrombopag | Tablet, Oral | Mulpleta | 2018 | 29 September 2031 |
| Clevidipine | Emulsion, Intravenous | Cleviprex | 2008 | 10 October 2031 |
| Beclomethasone Dipropionate | Aerosol, Metered, Nasal | Qnasl | 2012 | 21 October 2031 |
| Crofelemer | Tablet, Delayed Release, Oral | Mytesi | 2012 | 31 October 2031 |
| Betamethasone Dipropionate; Calcipotriene | Aerosol, Foam, Topical | Enstilar | 2015 | 10 December 2031 |
| Ertugliflozin | Tablet, Oral | Steglatro | 2017 | 19 December 2031 |
| Ertugliflozin; Metformin Hydrochloride | Tablet, Oral | Segluromet | 2017 | 19 December 2031 |
| Ertugliflozin; Sitagliptin Phosphate | Tablet, Oral | Steglujan | 2017 | 19 December 2031 |
| Sodium Nitrite | Solution, Intravenous | Sodium Nitrite | 2012 | 24 December 2031 |
| Sodium Nitrite; Sodium Thiosulfate | Solution, Solution, Intravenous, Intravenous | Nithiodote | 2011 | 24 December 2031 |
| Iloperidone | Tablet, Oral | Fanapt | 2009 | 28 December 2031 |
| Chlorpheniramine Maleate; Codeine Phosphate | Tablet, Extended Release, Oral | Tuxarin Er | 2015 | 3 January 2032 |
| Treosulfan | Powder, Intravenous | Grafapex | 2025 | 21 January 2032 |
| Moxidectin | Tablet, Oral | Moxidectin | 2018 | 7 February 2032 |
| Cabozantinib S-Malate | Capsule, Oral | Cometriq | 2012 | 10 February 2032 |
| Leniolisib Phosphate | Tablet, Oral | Joenja | 2023 | 19 February 2032 |
| Rotigotine | Film, Extended Release, Transdermal | Neupro | 2007 | 1 March 2032 |
| Ibuprofen | Solution, Intravenous | Caldolor | 2009 | 16 March 2032 |
| Nepafenac | Suspension/Drops, Ophthalmic | Ilevro, Nevanac | 2005 | 31 March 2032 |
| Naloxegol Oxalate | Tablet, Oral | Movantik | 2014 | 2 April 2032 |
| Risperidone | For Suspension, Extended Release, Intramuscular | Rykindo | 2023 | 10 April 2032 |
| Degarelix Acetate | Powder, Subcutaneous | Firmagon | 2008 | 27 April 2032 |
| Amoxicillin; Clarithromycin; Vonoprazan Fumarate | Capsule, Tablet, Tablet, Oral | Voquezna Triple Pak | 2022 | 3 May 2032 |
| Amoxicillin; Vonoprazan Fumarate | Capsule, Tablet, Oral | Voquezna Dual Pak | 2022 | 3 May 2032 |
| Vonoprazan Fumarate | Tablet, Oral | Voquezna | 2023 | 3 May 2032 |
| Polidocanol | Solution, Intravenous | Asclera, Varithena | 2010 | 12 May 2032 |
| Flortaucipir F-18 | Solution, Intravenous | Tauvid | 2020 | 26 May 2032 |
| Vemurafenib | Tablet, Oral | Zelboraf | 2011 | 6 June 2032 |
| Avibactam Sodium; Ceftazidime | Powder, Intravenous | Avycaz | 2015 | 15 June 2032 |
| Defibrotide Sodium | Solution, Intravenous | Defitelio | 2016 | 22 June 2032 |
| Regorafenib | Tablet, Oral | Stivarga | 2012 | 9 July 2032 |
| Florbetaben F-18 | Solution, Intravenous | Neuraceq | 2014 | 14 July 2032 |
| Avatrombopag Maleate | Granule, Oral | Doptelet Sprinkle | 2025 | 24 July 2032 |
| Avatrombopag Maleate | Tablet, Oral | Doptelet | 2018 | 24 July 2032 |
| Tecovirimat | Capsule, Oral | Tpoxx | 2018 | 8 August 2032 |
| Gallium Dotatate Ga-68 | Powder, Intravenous | Netspot | 2016 | 10 August 2032 |
| Doravirine | Tablet, Oral | Pifeltro | 2018 | 30 August 2032 |
| Doravirine; Islatravir | Tablet, Oral | Idvynso | 2026 | 30 August 2032 |
| Vortioxetine Hydrobromide | Tablet, Oral | Trintellix | 2013 | 21 September 2032 |
| Aspirin | Capsule, Oral | Vazalore | 2013 | 29 September 2032 |
| Atazanavir Sulfate; Cobicistat | Tablet, Oral | Evotaz | 2015 | 6 October 2032 |
| Cobicistat; Darunavir Ethanolate | Tablet, Oral | Prezcobix | 2015 | 6 October 2032 |
| Minocycline Hydrochloride | Injectable, Injection | Minocin | before 1982 | 16 October 2032 |
| Talazoparib Tosylate | Capsule, Oral | Talzenna | 2018 | 16 October 2032 |
| Dehydrated Alcohol | Solution, Intravenous | Dehydrated Alcohol | 2025 | 23 October 2032 |
| Selumetinib Sulfate | Capsule, Oral | Koselugo | 2020 | 19 November 2032 |
| Selumetinib Sulfate | Granule, Oral | Koselugo | 2025 | 19 November 2032 |
| Estradiol; Progesterone | Capsule, Oral | Bijuva | 2018 | 21 November 2032 |
| Vericiguat | Tablet, Oral | Verquvo | 2021 | 26 November 2032 |
| Opicapone | Capsule, Oral | Ongentys | 2020 | 12 December 2032 |
| Buprenorphine Hydrochloride | Film, Buccal | Belbuca | 2015 | 21 December 2032 |
| Methotrexate Sodium | Solution, Oral | Xatmep | 2017 | 2 January 2033 |
| Cetirizine Hydrochloride | Solution/Drops, Ophthalmic | Zerviate | 2017 | 9 January 2033 |
| Copper Histidinate | Powder, Subcutaneous | Zycubo | 2026 | 12 January 2033 |
| Afamelanotide | Implant, Subcutaneous | Scenesse | 2019 | 20 January 2033 |
| Baxdrostat | Tablet, Oral | Baxfendy | 2026 | 4 February 2033 |
| Avibactam Sodium; Aztreonam | Powder, Intravenous | Emblaveo | 2025 | 7 February 2033 |
| Sarecycline Hydrochloride | Tablet, Oral | Seysara | 2018 | 9 February 2033 |
| Emtricitabine; Rilpivirine Hydrochloride; Tenofovir Alafenamide Fumarate | Tablet, Oral | Odefsey | 2016 | 15 February 2033 |
| Doxylamine Succinate; Pyridoxine Hydrochloride | Tablet, Extended Release, Oral | Bonjesta | 2016 | 18 February 2033 |
| Glycopyrronium Tosylate | Cloth, Topical | Qbrexza | 2018 | 28 February 2033 |
| Letermovir | Solution, Intravenous | Prevymis | 2017 | 28 February 2033 |
| Nitisinone | Suspension, Oral | Orfadin | 2016 | 28 February 2033 |
| Eluxadoline | Tablet, Oral | Viberzi | 2015 | 14 March 2033 |
| Ledipasvir; Sofosbuvir | Pellets, Oral | Harvoni | 2019 | 14 March 2033 |
| Citric Acid; Lactic Acid; Potassium Bitartrate | Gel, Vaginal | Phexx | 2020 | 15 March 2033 |
| Esmolol Hydrochloride | Solution, Intravenous | Esmolol Hydrochloride Double Strength In Plastic Container, Esmolol Hydrochloride In Plastic Container | 2016 | 15 March 2033 |
| Linerixibat | Tablet, Oral | Lynavoy | 2026 | 17 March 2033 |
| Lefamulin Acetate | Tablet, Oral | Xenleta | 2019 | 25 March 2033 |
| Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide Fumarate | Tablet, Oral | Genvoya | 2015 | 6 April 2033 |
| Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Disoproxil Fumarate | Tablet, Oral | Stribild | 2012 | 6 April 2033 |
| Cytarabine; Daunorubicin | Powder, Intravenous | Vyxeos | 2017 | 15 April 2033 |
| Capivasertib | Tablet, Oral | Truqap | 2023 | 16 April 2033 |
| Aripiprazole | Suspension, Extended Release, Intramuscular | Abilify Asimtufii | 2023 | 23 April 2033 |
| Omaveloxolone | Capsule, Oral | Skyclarys | 2023 | 24 April 2033 |
| Naldemedine Tosylate | Tablet, Oral | Symproic | 2017 | 13 May 2033 |
| Suvorexant | Tablet, Oral | Belsomra | 2014 | 29 May 2033 |
| Trifarotene | Cream, Topical | Aklief | 2019 | 30 May 2033 |
| Taletrectinib Adipate | Capsule, Oral | Ibtrozi | 2025 | 3 June 2033 |
| Halobetasol Propionate | Lotion, Topical | Bryhali, Ultravate | 2015 | 19 June 2033 |
| Encorafenib | Capsule, Oral | Braftovi | 2018 | 5 August 2033 |
| Methylphenidate Hydrochloride | Tablet, Extended Release, Chewable, Oral | Quillichew Er | 2015 | 14 August 2033 |
| Ivacaftor | Granule, Oral | Kalydeco | 2015 | 27 August 2033 |
| Idelalisib | Tablet, Oral | Zydelig | 2014 | 2 September 2033 |
| Asenapine | System, Transdermal | Secuado | 2019 | 22 September 2033 |
| Quizartinib Dihydrochloride | Tablet, Oral | Vanflyta | 2023 | 30 September 2033 |
| Patiromer Sorbitex Calcium | Powder, Oral | Veltassa | 2015 | 8 October 2033 |
| Binimetinib | Tablet, Oral | Mektovi | 2018 | 18 October 2033 |
| Levodopa | Powder, Inhalation | Inbrija | 2018 | 21 October 2033 |
| Finafloxacin | Suspension/Drops, Otic | Xtoro | 2014 | 21 November 2033 |
| Spinosad | Suspension, Topical | Natroba | 2011 | 25 November 2033 |
| Ponatinib Hydrochloride | Tablet, Oral | Iclusig | 2012 | 12 December 2033 |
| Sildenafil Citrate | Film, Oral | Vybrique | 2025 | 16 December 2033 |
| Lifitegrast | Solution/Drops, Ophthalmic | Xiidra | 2016 | 18 December 2033 |
| Lorazepam | Capsule, Extended Release, Oral | Loreev Xr | 2021 | 8 January 2034 |
| Remimazolam Besylate | Powder, Intravenous | Byfavo | 2020 | 13 January 2034 |
| Melphalan Hydrochloride | Powder, Intravenous | Evomela | 2016 | 30 January 2034 |
| Dabrafenib Mesylate | Capsule, Oral | Tafinlar | 2013 | 28 February 2034 |
| Elamipretide Hydrochloride | Solution, Subcutaneous | Forzinity | 2025 | 28 February 2034 |
| Trametinib Dimethyl Sulfoxide | Tablet, Oral | Mekinist | 2013 | 28 February 2034 |
| Morphine Sulfate | Solution, Intramuscular, Intravenous | Morphine Sulfate | 2013 | 12 March 2034 |
| Calcifediol | Capsule, Extended Release, Oral | Rayaldee | 2016 | 14 March 2034 |
| Cyclobenzaprine Hydrochloride | Tablet, Sublingual | Tonmya | 2025 | 14 March 2034 |
| Eteplirsen | Solution, Intravenous | Exondys 51 | 2016 | 14 March 2034 |
| Latanoprost; Netarsudil Dimesylate | Solution/Drops, Ophthalmic | Rocklatan | 2019 | 14 March 2034 |
| Levetiracetam | Tablet, For Suspension, Oral | Spritam | 2015 | 14 March 2034 |
| Netarsudil Mesylate | Solution/Drops, Ophthalmic | Rhopressa | 2017 | 14 March 2034 |
| Rusfertide Acetate | Powder, Subcutaneous | Mimrylo | 2026 | 17 March 2034 |
| Testosterone | Gel, Metered, Nasal | Natesto | 2014 | 17 March 2034 |
| Fezolinetant | Tablet, Oral | Veozah | 2023 | 28 March 2034 |
| Ceftobiprole Medocaril Sodium | Powder, Intravenous | Zevtera | 2024 | 3 April 2034 |
| Viltolarsen | Solution, Intravenous | Viltepso | 2020 | 3 April 2034 |
| Landiolol Hydrochloride | Powder, Intravenous | Rapiblyk | 2024 | 25 April 2034 |
| Luliconazole | Cream, Topical | Luzu | 2013 | 28 April 2034 |
| Olezarsen Sodium | Solution, Subcutaneous | Tryngolza (Autoinjector) | 2024 | 1 May 2034 |
| Cipepofol | Emulsion, Intravenous | Cypsedo | 2026 | 6 May 2034 |
| Hydrocortisone | Granule, Oral | Alkindi Sprinkle | 2020 | 12 May 2034 |
| Delafloxacin Meglumine | Powder, Intravenous | Baxdela | 2017 | 2 June 2034 |
| Plecanatide | Tablet, Oral | Trulance | 2017 | 5 June 2034 |
| Zavegepant Hydrochloride | Spray, Metered, Nasal | Zavzpret | 2023 | 26 June 2034 |
| Etelcalcetide | Solution, Intravenous | Parsabiv | 2017 | 27 June 2034 |
| Bupropion Hydrochloride; Naltrexone Hydrochloride | Tablet, Extended Release, Oral | Contrave | 2014 | 2 July 2034 |
| Setmelanotide Acetate | Solution, Subcutaneous | Imcivree | 2020 | 4 July 2034 |
| Avacincaptad Pegol Sodium | Solution, Intravitreal | Izervay | 2023 | 11 July 2034 |
| Ruxolitinib Phosphate | Tablet, Extended Release, Oral | Jakafi Xr | 2026 | 17 July 2034 |
| Brincidofovir | Suspension, Oral | Tembexa | 2021 | 30 July 2034 |
| Ledipasvir; Sofosbuvir | Tablet, Oral | Harvoni | 2014 | 30 July 2034 |
| Rizatriptan Benzoate | Film, Oral | Rizafilm | 2023 | 30 July 2034 |
| Sofosbuvir; Velpatasvir | Pellets, Oral | Epclusa | 2021 | 30 July 2034 |
| Sofosbuvir; Velpatasvir | Tablet, Oral | Epclusa | 2016 | 30 July 2034 |
| Palbociclib | Capsule, Oral | Ibrance | 2015 | 8 August 2034 |
| Eplontersen Sodium | Solution, Subcutaneous | Wainua, Wainua (Autoinjector) | 2023 | 25 August 2034 |
| Bosutinib Monohydrate | Capsule, Oral | Bosulif | 2023 | 28 August 2034 |
| Pegulicianine Acetate | Powder, Intravenous | Lumisight | 2024 | 14 September 2034 |
| Enasidenib Mesylate | Tablet, Oral | Idhifa | 2017 | 16 September 2034 |
| Melphalan Hydrochloride | Powder, Intra-Arterial | Hepzato | 2023 | 17 September 2034 |
| Givosiran Sodium | Solution, Subcutaneous | Givlaari | 2019 | 3 October 2034 |
| Brincidofovir | Tablet, Oral | Tembexa | 2021 | 10 October 2034 |
| Bimatoprost | Implant, Ophthalmic | Durysta | 2020 | 31 October 2034 |
| Triheptanoin | Liquid, Oral | Dojolvi | 2020 | 14 November 2034 |
| Empagliflozin; Metformin Hydrochloride | Tablet, Oral | Synjardy | 2015 | 17 November 2034 |
| Mometasone Furoate | Implant, Implantation | Sinuva | 2017 | 24 November 2034 |
| Fidaxomicin | For Suspension, Oral | Dificid | 2020 | 28 November 2034 |
| Daridorexant Hydrochloride | Tablet, Oral | Quviviq | 2022 | 2 December 2034 |
| Empagliflozin; Metformin Hydrochloride | Tablet, Extended Release, Oral | Synjardy Xr | 2016 | 11 December 2034 |
| Nitisinone | Tablet, Oral | Harliku, Nityr | 2017 | 5 January 2035 |
| Diclofenac Epolamine | System, Topical | Flector, Licart | 2007 | 20 February 2035 |
| Sitagliptin | Tablet, Oral | Zituvio | 2023 | 25 February 2035 |
| Monomethyl Fumarate | Capsule, Delayed Release, Oral | Bafiertam | 2020 | 27 February 2035 |
| Pemetrexed Disodium | Solution, Intravenous | Pemetrexed, Pemetrexed Disodium | 2022 | 26 March 2035 |
| Tofersen | Solution, Intrathecal | Qalsody | 2023 | 1 April 2035 |
| Viloxazine Hydrochloride | Capsule, Extended Release, Oral | Qelbree | 2021 | 2 April 2035 |
| Ivacaftor; Ivacaftor, Tezacaftor | Tablet, Oral | Symdeko (Copackaged) | 2018 | 14 April 2035 |
| Alectinib Hydrochloride | Capsule, Oral | Alecensa | 2015 | 24 April 2035 |
| Duvelisib | Capsule, Oral | Copiktra | 2018 | 26 April 2035 |
| Donidalorsen Sodium | Solution, Subcutaneous | Dawnzera (Autoinjector) | 2025 | 1 May 2035 |
| Amikacin Sulfate | Suspension, Liposomal, Inhalation | Arikayce Kit | 2018 | 15 May 2035 |
| Ferric Oxyhydroxide | Tablet, Chewable, Oral | Velphoro | 2013 | 26 May 2035 |
| Florquinitau F-18 | Solution, Intravenous | Tauklarify | 2026 | 9 June 2035 |
| Zilucoplan Sodium | Solution, Subcutaneous | Zilbrysq | 2023 | 12 June 2035 |
| Tovorafenib | For Suspension, Oral | Ojemda | 2024 | 23 June 2035 |
| Tovorafenib | Tablet, Oral | Ojemda | 2024 | 23 June 2035 |
| Metoprolol Succinate | Capsule, Extended Release, Oral | Kapspargo Sprinkle | 2018 | 9 July 2035 |
| Berdazimer Sodium | Gel, Topical | Zelsuvmi | 2024 | 10 July 2035 |
| Oritavancin Diphosphate | Powder, Intravenous | Kimyrsa, Orbactiv | 2014 | 16 July 2035 |
| Capmatinib Hydrochloride | Tablet, Oral | Tabrecta | 2020 | 22 July 2035 |
| Finerenone | Tablet, Oral | Kerendia | 2021 | 29 July 2035 |
| Selinexor | Tablet, Oral | Xpovio | 2019 | 14 August 2035 |
| Rucaparib Camsylate | Tablet, Oral | Rubraca | 2016 | 17 August 2035 |
| Brepocitinib Tosylate | Tablet, Oral | Lisraya | 2026 | 19 August 2035 |
| Patisiran Sodium | Solution, Intravenous | Onpattro | 2018 | 27 August 2035 |
| Sotalol Hydrochloride | Solution, Oral | Sotylize | 2014 | 31 August 2035 |
| Tafamidis | Capsule, Oral | Vyndamax | 2019 | 31 August 2035 |
| Cefiderocol Sulfate Tosylate | Powder, Intravenous | Fetroja | 2019 | 3 September 2035 |
| Fruquintinib | Capsule, Oral | Fruzaqla | 2023 | 7 September 2035 |
| Aprepitant | Emulsion, Intravenous | Aponvie, Aprepitant, Cinvanti | 2017 | 18 September 2035 |
| Netupitant; Palonosetron Hydrochloride | Capsule, Oral | Akynzeo | 2014 | 25 September 2035 |
| Osilodrostat Phosphate | Tablet, Oral | Isturisa | 2020 | 12 October 2035 |
| Varenicline Tartrate | Spray, Nasal | Tyrvaya | 2021 | 19 October 2035 |
| Lemborexant | Tablet, Oral | Dayvigo | 2020 | 21 October 2035 |
| Ferric Maltol | Capsule, Oral | Accrufer | 2019 | 23 October 2035 |
| Methotrexate | Solution, Oral | Jylamvo | 2022 | 28 October 2035 |
| Vancomycin Hydrochloride | Solution, Intravenous | Tyzavan, Vancomycin Hydrochloride In Plastic Container | 1993 | 6 November 2035 |
| Brigatinib | Tablet, Oral | Alunbrig | 2017 | 10 November 2035 |
| Diazoxide Choline | Tablet, Extended Release, Oral | Vykat Xr | 2025 | 12 November 2035 |
| Durlobactam Sodium; Durlobactam Sodium; Sulbactam Sodium | Powder, Intravenous | Xacduro (Copackaged) | 2023 | 17 November 2035 |
| Pafolacianine Sodium | Solution, Intravenous | Cytalux | 2021 | 29 November 2035 |
| Tafenoquine Succinate | Tablet, Oral | Arakoda, Krintafel | 2018 | 2 December 2035 |
| Glecaprevir; Pibrentasvir | Pellets, Oral | Mavyret | 2021 | 5 December 2035 |
| Zoliflodacin | For Suspension, Oral | Nuzolvence | 2025 | 12 December 2035 |
| Xenon Xe-129 Hyperpolarized | Gas, Inhalation | Xenoview | 2022 | 29 December 2035 |
| Abrocitinib | Tablet, Oral | Cibinqo | 2022 | 14 January 2036 |
| Acetaminophen; Ibuprofen Sodium | Solution, Intravenous | Combogesic Iv | 2023 | 14 January 2036 |
| Fingolimod Lauryl Sulfate | Tablet, Orally Disintegrating, Oral | Tascenso Odt | 2021 | 19 January 2036 |
| Air Polymer-Type A | Foam, Intrauterine | Exem Foam Kit | 2019 | 11 February 2036 |
| Eflornithine Hydrochloride | Tablet, Oral | Iwilfin | 2023 | 12 February 2036 |
| Ceftolozane Sulfate; Tazobactam Sodium | Powder, Intravenous | Zerbaxa | 2014 | 14 February 2036 |
| Pemetrexed | Solution, Intravenous | Pemetrexed, Pemfexy | 2020 | 19 February 2036 |
| Nusinersen Sodium | Solution, Intrathecal | Spinraza | 2016 | 4 March 2036 |
| Gallium Ga-68 Gozetotide | Powder, Intravenous | Gozellix, Illuccix, Locametz | 2021 | 9 March 2036 |
| Oteseconazole | Capsule, Oral | Vivjoa | 2022 | 17 March 2036 |
| Sonidegib Phosphate | Capsule, Oral | Odomzo | 2015 | 30 March 2036 |
| Vadadustat | Tablet, Oral | Vafseo | 2024 | 31 March 2036 |
| Glasdegib Maleate | Tablet, Oral | Daurismo | 2018 | 13 April 2036 |
| Bupivacaine; Meloxicam | Solution, Extended Release, Periarticular | Zynrelef Kit | 2021 | 21 April 2036 |
| Glucagon | Solution, Subcutaneous | Gvoke Hypopen, Gvoke Kit, Gvoke Pfs | 2019 | 22 April 2036 |
| Siponimod | Tablet, Oral | Mayzent | 2019 | 23 April 2036 |
| Isopropyl Alcohol | Solution, Topical | Zuragard | 2019 | 24 April 2036 |
| Mavacamten | Capsule, Oral | Camzyos | 2022 | 28 April 2036 |
| Amino Acids; Calcium Chloride; Dextrose; Magnesium Sulfate; Potassium Chloride; Sodium Acetate; Sodium Glycerophosphate; Soybean Oil | Emulsion, Intravenous | Kabiven In Plastic Container, Perikabiven In Plastic Container | 2014 | 3 May 2036 |
| Clobetasol Propionate | Suspension/Drops, Ophthalmic | Byqlovi | 2024 | 9 May 2036 |
| Docetaxel | Solution, Intravenous | Beizray, Docivyx | 2022 | 16 May 2036 |
| Celecoxib | Solution, Oral | Elyxyb | 2020 | 27 May 2036 |
| Cefepime Hydrochloride; Zidebactam | Powder, Intravenous | Zaynich | 2026 | 29 May 2036 |
| Bimatoprost | Gel, Ophthalmic | Zolymbus | 2025 | 8 June 2036 |
| Lefamulin Acetate | Solution, Intravenous | Xenleta | 2019 | 14 June 2036 |
| Etrasimod Arginine | Tablet, Oral | Velsipity | 2023 | 21 June 2036 |
| Ferric Derisomaltose | Solution, Intravenous | Monoferric | 2020 | 22 June 2036 |
| Melphalan Hydrochloride | Solution, Intravenous | Ivra | 2023 | 29 June 2036 |
| Acalabrutinib | Capsule, Oral | Calquence | 2017 | 1 July 2036 |
| Acalabrutinib Maleate | Tablet, Oral | Calquence | 2022 | 1 July 2036 |
| Gilteritinib Fumarate | Tablet, Oral | Xospata | 2018 | 1 July 2036 |
| Repotrectinib | Capsule, Oral | Augtyro | 2023 | 24 July 2036 |
| Vutrisiran Sodium | Solution, Subcutaneous | Amvuttra | 2022 | 28 July 2036 |
| Tradipitant | Capsule, Oral | Nereus | 2025 | 9 August 2036 |
| Inclisiran Sodium | Solution, Subcutaneous | Leqvio | 2021 | 25 August 2036 |
| Oxycodone | Capsule, Extended Release, Oral | Xtampza Er | 2016 | 2 September 2036 |
| Ibrutinib | Tablet, Oral | Imbruvica | 2018 | 3 September 2036 |
| Testosterone Enanthate | Solution, Subcutaneous | Xyosted (Autoinjector) | 2018 | 4 September 2036 |
| Amphetamine; Amphetamine Aspartate/Dextroamphetamine Sulfate | Suspension, Extended Release, Oral | Dyanavel Xr | 2015 | 7 September 2036 |
| Clindamycin Phosphate | Gel, Vaginal | Xaciato | 2021 | 22 September 2036 |
| Dextromethorphan Hydrobromide; Guaifenesin; Naproxen Sodium | Tablet, Extended Release, Oral | Mucinex 12hr Cold & Fever Multi-Symptom | 2025 | 11 October 2036 |
| Letrozole; Ribociclib Succinate | Tablet, Oral | Kisqali Femara Co-Pack (Copackaged) | 2017 | 14 October 2036 |
| Ribociclib Succinate | Tablet, Oral | Kisqali | 2017 | 14 October 2036 |
| Irinotecan Hydrochloride | Injectable, Liposomal, Intravenous | Onivyde | 2015 | 15 October 2036 |
| Sodium Phenylbutyrate | For Suspension, Oral | Olpruva | 2022 | 17 October 2036 |
| Upadacitinib | Solution, Oral | Rinvoq Lq | 2024 | 17 October 2036 |
| Bictegravir Sodium; Emtricitabine; Tenofovir Alafenamide Fumarate | Tablet, Oral | Biktarvy | 2018 | 8 November 2036 |
| Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate | Tablet, Oral | Delstrigo | 2018 | 29 November 2036 |
| Levothyroxine Sodium | Solution, Intravenous | Levothyroxine Sodium | 2019 | 1 December 2036 |
| Fitusiran Sodium | Solution, Subcutaneous | Qfitlia | 2025 | 7 December 2036 |
| Omeprazole | Tablet, Orally Disintegrating, Delayed Release, Oral | Omeprazole | 2017 | 8 December 2036 |
| Glecaprevir; Pibrentasvir | Tablet, Oral | Mavyret | 2017 | 24 December 2036 |
| Cobimetinib Fumarate | Tablet, Oral | Cotellic | 2015 | 30 December 2036 |
| Difamilast | Ointment, Topical | Adquey | 2026 | 31 December 2036 |
| Copper | System, Intrauterine | Miudella, Paragard T 380a | 1984 | 23 January 2037 |
| Dordaviprone Hydrochloride | Capsule, Oral | Modeyso | 2025 | 30 January 2037 |
| Sacubitril; Valsartan | Capsule, Pellets, Oral | Entresto Sprinkle | 2024 | 2 February 2037 |
| Cocaine Hydrochloride | Solution, Nasal | Goprelto, Numbrino | 2017 | 7 February 2037 |
| Cysteamine Bitartrate | Capsule, Delayed Release, Oral | Procysbi | 2013 | 16 February 2037 |
| Cysteamine Bitartrate | Granule, Delayed Release, Oral | Procysbi | 2020 | 16 February 2037 |
| Alpelisib | Tablet, Oral | Piqray, Vijoice | 2019 | 17 February 2037 |
| Alpelisib | Granule, Oral | Vijoice | 2024 | 17 February 2037 |
| Palbociclib | Tablet, Oral | Ibrance | 2019 | 19 February 2037 |
| Enzalutamide | Capsule, Oral | Xtandi | 2012 | 23 February 2037 |
| Amifampridine Phosphate | Tablet, Oral | Firdapse | 2018 | 25 February 2037 |
| Terlipressin Acetate | Powder, Intravenous | Terlivaz | 2022 | 5 April 2037 |
| Levacetylleucine | For Suspension, Oral | Aqneursa | 2024 | 19 April 2037 |
| Perflutren | Injectable, Intravenous | Definity, Definity Rt | 2001 | 4 May 2037 |
| Treprostinil Sodium | Powder, Inhalation | Yutrepia | 2025 | 5 May 2037 |
| Larotrectinib Sulfate | Capsule, Oral | Vitrakvi | 2018 | 16 May 2037 |
| Larotrectinib Sulfate | Solution, Oral | Vitrakvi | 2018 | 16 May 2037 |
| Thiotepa | Powder, Intravenous | Tepadina And Sodium Chloride | 2025 | 31 May 2037 |
| Ensartinib Hydrochloride | Capsule, Oral | Ensacove | 2024 | 1 June 2037 |
| Fosnetupitant Chloride Hydrochloride; Palonosetron Hydrochloride | Solution, Intravenous | Akynzeo | 2020 | 2 June 2037 |
| Atorvastatin Calcium | Suspension, Oral | Atorvaliq | 2023 | 7 June 2037 |
| Piflufolastat F-18 | Solution, Intravenous | Pylarify, Pylarify Truvu | 2021 | 9 June 2037 |
| Perfluorohexyloctane | Solution/Drops, Ophthalmic | Miebo | 2023 | 21 June 2037 |
| Palovarotene | Capsule, Oral | Sohonos | 2023 | 16 August 2037 |
| Zuranolone | Capsule, Oral | Zurzuvae | 2023 | 23 August 2037 |
| Roflumilast | Cream, Topical | Zoryve | 2022 | 25 August 2037 |
| Minocycline Hydrochloride | Aerosol, Foam, Topical | Amzeeq, Zilxi | 2019 | 8 September 2037 |
| Pimavanserin Tartrate | Tablet, Oral | Nuplazid | 2016 | 23 September 2037 |
| Orforglipron Calcium | Tablet, Oral | Foundayo | 2026 | 26 September 2037 |
| Relugolix | Tablet, Oral | Orgovyx | 2020 | 29 September 2037 |
| Sparsentan | Tablet, Oral | Filspari | 2023 | 13 October 2037 |
| Eravacycline Dihydrochloride | Powder, Intravenous | Xerava | 2018 | 19 October 2037 |
| Rilpivirine Hydrochloride | Tablet, For Suspension, Oral | Edurant Ped | 2024 | 23 October 2037 |
| Omadacycline Tosylate | Powder, Intravenous | Nuzyra | 2018 | 31 October 2037 |
| Omadacycline Tosylate | Tablet, Oral | Nuzyra | 2018 | 31 October 2037 |
| Benoxinate Hydrochloride; Fluorescein Sodium | Solution/Drops, Ophthalmic | Altafluor Benox, Fluorescein Sodium And Benoxinate Hydrochloride | 2017 | 15 November 2037 |
| Sofosbuvir; Velpatasvir; Voxilaprevir | Tablet, Oral | Vosevi | 2017 | 1 December 2037 |
| Voclosporin | Capsule, Oral | Lupkynis | 2021 | 7 December 2037 |
| Empagliflozin; Linagliptin | Tablet, Oral | Glyxambi | 2015 | 8 December 2037 |
| Empagliflozin; Linagliptin; Metformin Hydrochloride | Tablet, Extended Release, Oral | Trijardy Xr | 2020 | 8 December 2037 |
| Linagliptin; Metformin Hydrochloride | Tablet, Extended Release, Oral | Jentadueto Xr | 2016 | 8 December 2037 |
| Dexmethylphenidate Hydrochloride; Serdexmethylphenidate Chloride | Capsule, Oral | Azstarys | 2021 | 9 December 2037 |
| Ceritinib | Tablet, Oral | Zykadia | 2019 | 13 December 2037 |
| Micafungin Sodium | Solution, Intravenous | Micafungin In Sodium Chloride 0.9% | 2023 | 15 December 2037 |
| Colchicine | Solution, Oral | Gloperba | 2019 | 20 December 2037 |
| Epinephrine | Solution, Intramuscular, Subcutaneous | Auvi-Q, Symjepi | 2012 | 21 December 2037 |
| Indigotindisulfonate Sodium | Solution, Intravenous | Bludigo | 2022 | 23 December 2037 |
| Hexaminolevulinate Hydrochloride | For Solution, Intravesical | Cysview Kit | 2010 | 4 January 2038 |
| Elacestrant Hydrochloride | Tablet, Oral | Orserdu | 2023 | 5 January 2038 |
| Aminolevulinic Acid Hydrochloride | Solution, Topical | Levulan | 1999 | 12 January 2038 |
| Citric Acid; Magnesium Oxide; Sodium Picosulfate | Solution, Oral | Clenpiq | 2017 | 27 January 2038 |
| Vepdegestrant | Tablet, Oral | Veppanu | 2026 | 30 January 2038 |
| Erdafitinib | Tablet, Oral | Balversa | 2019 | 2 February 2038 |
| Tebipenem Pivoxil Hydrobromide | Tablet, Oral | Utebzi | 2026 | 6 February 2038 |
| Amisulpride | Solution, Intravenous | Barhemsys | 2020 | 9 February 2038 |
| Upadacitinib | Tablet, Extended Release, Oral | Rinvoq | 2019 | 9 March 2038 |
| Seladelpar Lysine | Capsule, Oral | Livdelzi | 2024 | 13 March 2038 |
| Sincalide | Powder, Intravenous | Kinevac, Sincalide | 2022 | 20 April 2038 |
| Tucatinib | Tablet, Oral | Tukysa | 2020 | 27 April 2038 |
| Tazarotene | Lotion, Topical | Arazlo | 2019 | 11 May 2038 |
| Inavolisib | Tablet, Oral | Itovebi | 2024 | 14 June 2038 |
| Buprenorphine | Solution, Extended Release, Subcutaneous | Brixadi, Sublocade | 2017 | 22 June 2038 |
| Rezafungin Acetate | Powder, Intravenous | Rezzayo | 2023 | 14 July 2038 |
| Elexacaftor, Ivacaftor, Tezacaftor; Ivacaftor | Granule, Oral | Trikafta (Copackaged) | 2023 | 17 July 2038 |
| Elexacaftor, Ivacaftor, Tezacaftor; Ivacaftor | Tablet, Oral | Trikafta (Copackaged) | 2019 | 17 July 2038 |
| Entrectinib | Capsule, Oral | Rozlytrek | 2019 | 18 July 2038 |
| Cobicistat; Darunavir; Emtricitabine; Tenofovir Alafenamide Fumarate | Tablet, Oral | Symtuza | 2018 | 19 July 2038 |
| Pexidartinib Hydrochloride | Capsule, Oral | Turalio | 2019 | 24 July 2038 |
| Aprocitentan | Tablet, Oral | Tryvio | 2024 | 26 July 2038 |
| Danicopan | Tablet, Oral | Voydeya | 2024 | 2 August 2038 |
| Bictegravir Sodium, Lenacapavir Sodium; Lenacapavir Sodium | Tablet, Oral | Bixlenvo Sunlenca Starter Pack (Copackaged) | 2026 | 16 August 2038 |
| Bictegravir Sodium; Lenacapavir Sodium | Tablet, Oral | Bixlenvo | 2026 | 16 August 2038 |
| Zonisamide | Suspension, Oral | Zonisade | 2022 | 18 August 2038 |
| Tretinoin | Lotion, Topical | Altreno | 2018 | 22 August 2038 |
| Amantadine Hydrochloride | Capsule, Extended Release, Oral | Gocovri | 2017 | 23 August 2038 |
| Dolutegravir Sodium; Rilpivirine Hydrochloride | Tablet, Oral | Juluca | 2017 | 5 September 2038 |
| Tirbanibulin | Ointment, Topical | Klisyri | 2020 | 7 September 2038 |
| Plozasiran Sodium | Solution, Subcutaneous | Redemplo | 2025 | 10 September 2038 |
| Deutetrabenazine | Tablet, Oral | Austedo | 2017 | 15 September 2038 |
| Ozanimod Hydrochloride | Capsule, Oral | Zeposia | 2020 | 30 September 2038 |
| Lorlatinib | Tablet, Oral | Lorbrena | 2018 | 4 October 2038 |
| Budesonide; Formoterol Fumarate; Glycopyrrolate | Aerosol, Metered, Inhalation | Breztri Aerosphere | 2020 | 5 October 2038 |
| Nedosiran Sodium | Solution, Injection | Rivfloza | 2023 | 12 October 2038 |
| Nerandomilast | Tablet, Oral | Jascayd | 2025 | 22 October 2038 |
| Eltrombopag Choline | Tablet, Oral | Alvaiz | 2023 | 5 November 2038 |
| Gemcitabine Hydrochloride | System, Intravesical | Inlexzo | 2025 | 7 November 2038 |
| Lenvatinib Mesylate | Capsule, Oral | Lenvima | 2015 | 15 November 2038 |
| Metoclopramide Hydrochloride | Spray, Metered, Nasal | Gimoti | 2020 | 17 November 2038 |
| Mavorixafor | Capsule, Oral | Xolremdi | 2024 | 11 December 2038 |
| Lotilaner | Solution/Drops, Ophthalmic | Xdemvy | 2023 | 14 December 2038 |
| Pegcetacoplan | Solution, Intravitreal | Syfovre | 2023 | 14 December 2038 |
| Pegcetacoplan | Solution, Subcutaneous | Empaveli | 2021 | 14 December 2038 |
| Tadalafil | Suspension, Oral | Tadliq | 2022 | 24 December 2038 |
| Dabrafenib Mesylate | Tablet, For Suspension, Oral | Tafinlar | 2023 | 29 December 2038 |
| Fenfluramine Hydrochloride | Solution, Oral | Fintepla | 2020 | 29 December 2038 |
| Leuprolide Mesylate | Emulsion, Subcutaneous | Camcevi Etm, Camcevi Kit | 2021 | 1 January 2039 |
| Birch Triterpenes | Gel, Topical | Filsuvez | 2023 | 4 January 2039 |
| Minocycline Hydrochloride | Capsule, Extended Release, Oral | Emrosi | 2012 | 7 January 2039 |
| Budesonide | Suspension, Oral | Eohilia | 2024 | 10 January 2039 |
| Fosaprepitant Dimeglumine | Solution, Intravenous | Focinvez | 2023 | 11 January 2039 |
| Vorasidenib | Tablet, Oral | Voranigo | 2024 | 16 January 2039 |
| Niraparib Tosylate | Tablet, Oral | Zejula | 2023 | 25 January 2039 |
| Sebetralstat | Tablet, Oral | Ekterly | 2025 | 26 January 2039 |
| Sunvozertinib | Tablet, Oral | Zegfrovy | 2025 | 28 January 2039 |
| Fosfomycin Disodium | Powder, Intravenous | Contepo | 2025 | 30 January 2039 |
| Semaglutide | Tablet, Oral | Ozempic, Rybelsus, Wegovy | 2019 | 1 February 2039 |
| Epinephrine | Spray, Nasal | Neffy | 2024 | 6 February 2039 |
| Pimavanserin Tartrate | Capsule, Oral | Nuplazid | 2018 | 27 February 2039 |
| Cysteine Hydrochloride | Solution, Intravenous | Elcys, Nouress | 2019 | 15 March 2039 |
| Betamethasone Dipropionate; Calcipotriene | Cream, Topical | Wynzora | 2020 | 18 March 2039 |
| Epinephrine | Solution, Intravenous | Adrenalin, Epinephrine | 2019 | 21 March 2039 |
| Levoleucovorin | Powder, Intravenous | Khapzory | 2018 | 25 March 2039 |
| Rimegepant Sulfate | Tablet, Orally Disintegrating, Oral | Nurtec Odt | 2020 | 25 March 2039 |
| Aripiprazole Lauroxil | Suspension, Extended Release, Intramuscular | Aristada, Aristada Initio Kit | 2015 | 6 April 2039 |
| Meropenem; Vaborbactam | Powder, Intravenous | Vabomere | 2017 | 6 April 2039 |
| Selpercatinib | Tablet, Oral | Retevmo | 2024 | 10 April 2039 |
| Selpercatinib | Capsule, Oral | Retevmo | 2020 | 10 April 2039 |
| Amlodipine Benzoate | Suspension, Oral | Katerzia | 2019 | 11 April 2039 |
| Sonrotoclax | Tablet, Oral | Beqalzi | 2026 | 29 April 2039 |
| Trientine Tetrahydrochloride | Tablet, Oral | Cuvrior | 2022 | 3 May 2039 |
| Chloroprocaine Hydrochloride | Gel, Ophthalmic | Iheezo | 2022 | 14 May 2039 |
| Sulfur Hexafluoride Lipid-Type A Microspheres | For Suspension, Intravenous | Lumason | 2014 | 15 May 2039 |
| Bivalirudin | Solution, Intravenous | Angiomax Rtu | 2017 | 20 May 2039 |
| Ivosidenib | Tablet, Oral | Tibsovo | 2018 | 7 June 2039 |
| Ibrexafungerp Citrate | Tablet, Oral | Brexafemme | 2021 | 10 June 2039 |
| Ibrutinib | Suspension, Oral | Imbruvica | 2022 | 14 June 2039 |
| Cenobamate | Tablet, Oral | Xcopri | 2020 | 16 June 2039 |
| Imetelstat Sodium | Powder, Intravenous | Rytelo | 2024 | 16 June 2039 |
| Ethinyl Estradiol; Segesterone Acetate | Ring, Vaginal | Annovera | 2018 | 21 June 2039 |
| Sodium Thiosulfate | Solution, Intravenous | Pedmark, Sodium Thiosulfate | 2012 | 1 July 2039 |
| Imlunestrant Tosylate | Tablet, Oral | Inluriyo | 2025 | 11 July 2039 |
| Indocyanine Green | Powder, Intravenous, Interstitial | Spy Agent Green Kit | 2018 | 14 July 2039 |
| Omidenepag Isopropyl | Solution, Ophthalmic | Omlonti | 2022 | 16 July 2039 |
| Rocuronium Bromide | Solution, Intravenous | Rocuronium Bromide | 2025 | 22 July 2039 |
| Acoramidis Hydrochloride | Tablet, Oral | Attruby | 2024 | 16 August 2039 |
| Mycophenolate Mofetil | Suspension, Oral | Myhibbin | 2024 | 16 August 2039 |
| Sotalol Hydrochloride | Solution, Intravenous | Sotalol Hydrochloride | 2009 | 21 August 2039 |
| Dihydroergotamine Mesylate | Solution, Subcutaneous | Brekiya (Autoinjector) | 2025 | 24 August 2039 |
| Glucagon | Powder, Nasal | Baqsimi | 2019 | 23 September 2039 |
| Fedratinib Hydrochloride | Capsule, Oral | Inrebic | 2019 | 24 September 2039 |
| Iberdomide Hydrochloride | Capsule, Oral | Zenbexus | 2026 | 30 September 2039 |
| Metronidazole | Suspension, Oral | Likmez | 2023 | 4 October 2039 |
| Revefenacin | Solution, Inhalation | Yupelri | 2018 | 23 October 2039 |
| Phentolamine Mesylate | Solution, Ophthalmic | Ryzumvi | 2023 | 25 October 2039 |
| Trospium Chloride; Xanomeline Tartrate | Capsule, Oral | Cobenfy | 2024 | 29 October 2039 |
| Futibatinib | Tablet, Oral | Lytgobi | 2022 | 5 November 2039 |
| Nalmefene Hydrochloride | Solution, Intramuscular, Subcutaneous | Zurnai (Autoinjector) | 2024 | 5 November 2039 |
| Tivozanib Hydrochloride | Capsule, Oral | Fotivda | 2021 | 5 November 2039 |
| Olutasidenib | Capsule, Oral | Rezlidhia | 2022 | 12 November 2039 |
| Avacopan | Capsule, Oral | Tavneos | 2021 | 27 November 2039 |
| Oxymetazoline Hydrochloride | Solution/Drops, Ophthalmic | Upneeq, Visine L.r. | 1986 | 16 December 2039 |
| Tapinarof | Cream, Topical | Vtama | 2022 | 18 December 2039 |
| Probenecid; Sulopenem Etzadroxil | Tablet, Oral | Orlynvah | 2024 | 23 December 2039 |
| Abaloparatide | Solution, Subcutaneous | Tymlos | 2017 | 10 January 2040 |
| Gadopiclenol | Solution, Intravenous | Elucirem | 2022 | 17 January 2040 |
| Clobazam | Film, Oral | Sympazan | 2018 | 31 January 2040 |
| Enlicitide Decanoate | Tablet, Oral | Lipfendra | 2026 | 4 February 2040 |
| Amphetamine; Amphetamine Aspartate/Dextroamphetamine Sulfate | Tablet, Extended Release, Oral | Dyanavel Xr 10, Dyanavel Xr 15, Dyanavel Xr 20 | 2021 | 11 February 2040 |
| Maralixibat Chloride | Solution, Oral | Livmarli | 2021 | 12 February 2040 |
| Esketamine Hydrochloride | Spray, Nasal | Spravato | 2019 | 18 February 2040 |
| Nilotinib Tartrate | Tablet, Oral | Danziten | 2024 | 18 February 2040 |
| Brensocatib | Tablet, Oral | Brinsupri | 2025 | 21 February 2040 |
| Levoketoconazole | Tablet, Oral | Recorlev | 2021 | 2 March 2040 |
| Triamcinolone Acetonide | Suspension, Injection | Xipere | 2021 | 16 April 2040 |
| Imatinib Mesylate | Solution, Oral | Imkeldi | 2024 | 27 April 2040 |
| Berotralstat Dihydrochloride | Pellets, Oral | Orladeyo | 2025 | 1 May 2040 |
| Berotralstat Dihydrochloride | Capsule, Oral | Orladeyo | 2020 | 1 May 2040 |
| Givinostat Hydrochloride | Suspension, Oral | Duvyzat | 2024 | 3 May 2040 |
| Asciminib Hydrochloride | Tablet, Oral | Scemblix | 2021 | 17 May 2040 |
| Gadoquatrane | Solution, Intravenous | Ambelvist | 2026 | 19 May 2040 |
| Sofpironium Bromide | Gel, Metered, Topical | Sofdra | 2024 | 22 May 2040 |
| Lamotrigine | Suspension, Oral | Subvenite | 2025 | 29 May 2040 |
| Lacosamide | Capsule, Extended Release, Oral | Motpoly Xr | 2023 | 5 June 2040 |
| Foscarbidopa; Foslevodopa | Solution, Subcutaneous | Vyalev | 2024 | 10 June 2040 |
| Bempedoic Acid | Tablet, Oral | Nexletol | 2020 | 19 June 2040 |
| Bempedoic Acid; Ezetimibe | Tablet, Oral | Nexlizet | 2020 | 19 June 2040 |
| Vamorolone | Suspension, Oral | Agamree | 2023 | 16 July 2040 |
| Meloxicam | Solution, Intravenous | Qamzova | 2020 | 19 July 2040 |
| Doxecitine; Doxribtimine | For Solution, Oral | Kygevvi | 2025 | 19 August 2040 |
| Elagolix Sodium | Tablet, Oral | Orilissa | 2018 | 27 August 2040 |
| Elagolix Sodium,Estradiol,Norethindrone Acetate; Elagolix Sodium | Capsule, Oral | Oriahnn (Copackaged) | 2020 | 27 August 2040 |
| Lisdexamfetamine Dimesylate | Solution, Oral | Arynta | 2025 | 30 August 2040 |
| Levonorgestrel | System, Intrauterine | Kyleena, Liletta, Mirena | 2000 | 7 September 2040 |
| Sotorasib | Tablet, Oral | Lumakras | 2021 | 15 September 2040 |
| Cabotegravir; Rilpivirine | Suspension, Extended Release, Intramuscular | Cabenuva Kit | 2021 | 1 October 2040 |
| Pemigatinib | Tablet, Oral | Pemazyre | 2020 | 3 October 2040 |
| Sirolimus | Powder, Intravenous | Fyarro | 2021 | 28 October 2040 |
| Trilaciclib Dihydrochloride | Powder, Intravenous | Cosela | 2021 | 13 November 2040 |
| Momelotinib Dihydrochloride | Tablet, Oral | Ojjaara | 2023 | 2 December 2040 |
| Suzetrigine | Tablet, Oral | Journavx | 2025 | 4 December 2040 |
| Lumateperone Tosylate | Capsule, Oral | Caplyta | 2019 | 10 December 2040 |
| Adapalene; Benzoyl Peroxide; Clindamycin Phosphate | Gel, Topical | Cabtreo | 2023 | 28 December 2040 |
| Octreotide Acetate | Capsule, Delayed Release, Oral | Mycapssa | 2020 | 28 December 2040 |
| Naloxone Hydrochloride | Spray, Nasal | Kloxxado, Rezenopy | 2021 | 5 February 2041 |
| Semaglutide | Solution, Subcutaneous | Ozempic, Wegovy, Wegovy Flextouch | 2017 | 17 February 2041 |
| Cantharidin | Solution, Topical | Ycanth | 2023 | 19 February 2041 |
| Rilzabrutinib | Tablet, Oral | Wayrilz | 2025 | 20 February 2041 |
| Tasimelteon | Suspension, Oral | Hetlioz Lq | 2020 | 21 February 2041 |
| Calcium Oxybate; Magnesium Oxybate; Potassium Oxybate; Sodium Oxybate | Solution, Oral | Xywav | 2020 | 22 February 2041 |
| Amlodipine Besylate | Solution, Oral | Norliqva | 2022 | 24 February 2041 |
| Aripiprazole | For Suspension, Extended Release, Intramuscular | Abilify Maintena Kit | 2013 | 1 April 2041 |
| Risdiplam | For Solution, Oral | Evrysdi | 2020 | 15 April 2041 |
| Risdiplam | Tablet, Oral | Evrysdi | 2025 | 15 April 2041 |
| Baloxavir Marboxil | For Suspension, Oral | Xofluza | 2020 | 21 April 2041 |
| Dexamethasone | Insert, Ophthalmic | Dextenza | 2018 | 26 April 2041 |
| Testosterone Undecanoate | Capsule, Oral | Jatenzo, Kyzatrex, Tlando | 2019 | 28 April 2041 |
| Bremelanotide Acetate | Solution, Subcutaneous | Vyleesi (Autoinjector) | 2019 | 29 April 2041 |
| Nilotinib | Tablet, Orally Disintegrating, Oral | Cavhanza | 2026 | 30 April 2041 |
| Ruxolitinib Phosphate | Cream, Topical | Opzelura | 2021 | 5 May 2041 |
| Zilganersen Sodium | Solution, Intrathecal | Zanvastro | 2026 | 20 May 2041 |
| Apixaban | For Suspension, Oral | Eliquis Sprinkle | 2025 | 22 May 2041 |
| Benzoyl Peroxide | Cream, Topical | Epsolay | 2022 | 23 May 2041 |
| Benzoyl Peroxide; Tretinoin | Cream, Topical | Twyneo | 2021 | 23 May 2041 |
| Lumasiran Sodium | Solution, Subcutaneous | Oxlumo | 2020 | 29 May 2041 |
| Deutetrabenazine | Tablet, Extended Release, Oral | Austedo Xr | 2023 | 10 June 2041 |
| Naloxone Hydrochloride | Solution, Intramuscular, Subcutaneous | Zimhi | 2014 | 14 June 2041 |
| Ethinyl Estradiol; Norethindrone Acetate | Tablet, Orally Disintegrating, Oral | Femlyv | 2024 | 24 June 2041 |
| Cupric Sulfate; Manganese Sulfate; Selenious Acid; Zinc Sulfate | Solution, Intravenous | Multrys, Tralement | 2020 | 1 July 2041 |
| Iptacopan Hydrochloride | Capsule, Oral | Fabhalta | 2023 | 15 July 2041 |
| Zongertinib | Tablet, Oral | Hernexeos | 2025 | 21 July 2041 |
| Clonidine Hydrochloride | Suspension, Extended Release, Oral | Onyda Xr | 2024 | 28 July 2041 |
| Lomitapide Mesylate | Capsule, Oral | Juxtapid | 2012 | 29 July 2041 |
| Mitapivat Sulfate | Tablet, Oral | Aqvesme, Pyrukynd | 2022 | 31 July 2041 |
| Lazertinib Mesylate | Tablet, Oral | Lazcluze | 2024 | 1 August 2041 |
| Lenacapavir Sodium | Solution, Subcutaneous | Sunlenca, Yeztugo | 2022 | 28 August 2041 |
| Lenacapavir Sodium | Tablet, Oral | Sunlenca, Yeztugo | 2022 | 28 August 2041 |
| Copper Cu-64 Dotatate | Solution, Intravenous | Detectnet | 2020 | 3 September 2041 |
| Pirtobrutinib | Tablet, Oral | Jaypirca | 2023 | 14 September 2041 |
| Lutetium Lu-177 Vipivotide Tetraxetan | Solution, Intravenous | Pluvicto | 2022 | 18 September 2041 |
| Bexagliflozin | Tablet, Oral | Brenzavvy | 2023 | 5 October 2041 |
| Losartan Potassium | Suspension, Oral | Arbli | 2025 | 7 October 2041 |
| Dihydroergotamine Mesylate | Powder, Nasal | Atzumi | 2025 | 12 October 2041 |
| Ritlecitinib Tosylate | Capsule, Oral | Litfulo | 2023 | 17 October 2041 |
| Camizestrant | Tablet, Oral | Etcamah | 2026 | 22 October 2041 |
| Olaparib | Tablet, Oral | Lynparza | 2017 | 25 October 2041 |
| Nirmatrelvir; Ritonavir | Tablet, Oral | Paxlovid (Copackaged) | 2023 | 31 October 2041 |
| Edaravone | Suspension, Oral | Radicava Ors | 2022 | 12 November 2041 |
| Odevixibat | Capsule, Pellets, Oral | Bylvay | 2021 | 12 November 2041 |
| Odevixibat | Capsule, Oral | Bylvay | 2021 | 12 November 2041 |
| Olanzapine; Samidorphan L-Malate | Tablet, Oral | Lybalvi | 2021 | 12 November 2041 |
| Arimoclomol Citrate | Capsule, Oral | Miplyffa | 2024 | 19 November 2041 |
| Icotrokinra Hydrochloride | Tablet, Oral | Icotyde | 2026 | 19 November 2041 |
| Paliperidone Palmitate | Suspension, Extended Release, Intramuscular | Erzofri, Invega Hafyera, Invega Sustenna | 2009 | 24 November 2041 |
| Flotufolastat F-18 Gallium | Solution, Intravenous | Posluma | 2023 | 27 November 2041 |
| Remdesivir | Powder, Intravenous | Veklury | 2020 | 28 November 2041 |
| Secnidazole | Granule, Oral | Solosec | 2017 | 11 December 2041 |
| Aripiprazole | Film, Oral | Opipza | 2024 | 15 December 2041 |
| Carbidopa; Levodopa | Capsule, Extended Release, Oral | Crexont, Rytary | 2015 | 21 December 2041 |
| Leuprolide Acetate | Powder, Subcutaneous | Eligard Kit, Fensolvi Kit | 2002 | 22 December 2041 |
| Relacorilant | Capsule, Oral | Lifyorli (Copackaged) | 2026 | 22 December 2041 |
| Ubrogepant | Tablet, Oral | Ubrelvy | 2019 | 22 December 2041 |
| Hydroxyurea | Solution, Oral | Xromi | 2024 | 23 December 2041 |
| Motixafortide Acetate | Powder, Subcutaneous | Aphexda | 2023 | 29 December 2041 |
| Octreotide Acetate | Solution, Subcutaneous | Bynfezia Pen | 2024 | 29 December 2041 |
| Tirzepatide | Solution, Subcutaneous | Mounjaro, Mounjaro (Autoinjector), Mounjaro Kwikpen | 2022 | 30 December 2041 |
| Dextroamphetamine | System, Transdermal | Xelstrym | 2022 | 6 January 2042 |
| Furosemide | Solution, Subcutaneous | Furoscix, Furoscix Readyflow (Autoinjector), Lasix Onyu | 2022 | 10 January 2042 |
| Migalastat Hydrochloride | Capsule, Oral | Galafold | 2018 | 11 January 2042 |
| Daraxonrasib | Tablet, Oral | Rasonque | 2026 | 24 January 2042 |
| Treprostinil | Powder, Inhalation | Tyvaso Dpi | 2022 | 3 February 2042 |
| Treprostinil | Solution, Inhalation | Tyvaso | 2009 | 3 February 2042 |
| Sepiapterin | Powder, Oral | Sephience | 2025 | 6 March 2042 |
| Avapritinib | Tablet, Oral | Ayvakit | 2020 | 8 March 2042 |
| Sodium Oxybate | For Suspension, Extended Release, Oral | Lumryz | 2023 | 16 March 2042 |
| Risperidone | Suspension, Extended Release, Subcutaneous | Uzedy | 2023 | 17 March 2042 |
| Cyclosporine | Solution, Ophthalmic | Cequa, Vevye | 2018 | 1 April 2042 |
| Phenobarbital Sodium | Powder, Intravenous | Sezaby | 2022 | 7 April 2042 |
| Heparin Sodium; Taurolidine | Solution, N/A | Defencath | 2023 | 15 April 2042 |
| Fluciclovine F-18 | Solution, Intravenous | Axumin | 2016 | 23 April 2042 |
| Ensitrelvir | Tablet, Oral | Xocova | 2026 | 1 May 2042 |
| Tizanidine Hydrochloride | Solution, Oral | Ontralfy | 2024 | 7 May 2042 |
| Flurpiridaz F-18 | Solution, Intravenous | Flyrcado | 2024 | 13 May 2042 |
| Clotrimazole | Solution/Drops, Otic | Clotic | 2025 | 26 May 2042 |
| Amoxicillin; Omeprazole Magnesium; Rifabutin | Capsule, Delayed Release, Oral | Talicia | 2019 | 27 May 2042 |
| Apremilast | Tablet, Extended Release, Oral | Otezla Xr | 2025 | 27 May 2042 |
| Diazepam | Spray, Nasal | Valtoco | 2020 | 10 June 2042 |
| Darolutamide | Tablet, Oral | Nubeqa | 2019 | 17 June 2042 |
| Belzutifan | Tablet, Oral | Welireg | 2021 | 30 June 2042 |
| Vibegron | Tablet, Oral | Gemtesa | 2020 | 6 July 2042 |
| Vosoritide | Powder, Subcutaneous | Voxzogo | 2021 | 11 July 2042 |
| Belumosudil Mesylate | Tablet, Oral | Rezurock | 2021 | 14 July 2042 |
| Aficamten | Tablet, Oral | Myqorzo | 2025 | 15 July 2042 |
| Etripamil | Spray, Nasal | Cardamyst | 2025 | 15 July 2042 |
| Bendamustine Hydrochloride | Solution, Intravenous | Belrapzo, Bendamustine Hydrochloride, Bendeka | 2013 | 29 July 2042 |
| Nalmefene Hydrochloride | Spray, Nasal | Opvee | 2023 | 4 August 2042 |
| Roflumilast | Foam, Topical | Zoryve | 2023 | 19 August 2042 |
| Cannabidiol | Solution, Oral | Epidiolex | 2018 | 24 September 2042 |
| Ganaxolone | Suspension, Oral | Ztalmy | 2022 | 30 September 2042 |
| Zidesamtinib | Tablet, Oral | Jideytro | 2026 | 30 September 2042 |
| Ripretinib | Tablet, Oral | Qinlock | 2020 | 6 October 2042 |
| Estradiol; Norethindrone Acetate; Relugolix | Tablet, Oral | Myfembree | 2021 | 5 November 2042 |
| Brimonidine Tartrate; Carbachol | Solution/Drops, Ophthalmic | Yuvezzi | 2026 | 10 November 2042 |
| Navepegritide | Powder, Subcutaneous | Yuviwel | 2026 | 12 November 2042 |
| Palopegteriparatide | Solution, Subcutaneous | Yorvipath | 2024 | 12 November 2042 |
| Osimertinib Mesylate | Tablet, Oral | Tagrisso | 2015 | 26 November 2042 |
| Tenapanor Hydrochloride | Tablet, Oral | Ibsrela, Xphozah | 2019 | 26 November 2042 |
| Cedazuridine; Decitabine | Tablet, Oral | Inqovi | 2020 | 10 December 2042 |
| Gepotidacin Mesylate | Tablet, Oral | Blujepa | 2025 | 13 December 2042 |
| Acoltremon | Solution/Drops, Ophthalmic | Tryptyr | 2025 | 16 December 2042 |
| Revumenib Citrate | Tablet, Oral | Revuforj | 2024 | 18 December 2042 |
| Avutometinib Potassium; Defactinib Hydrochloride | Capsule, Tablet, Oral | Avmapki Fakzynja Co-Pack (Copackaged) | 2025 | 29 December 2042 |
| Deutivacaftor; Tezacaftor; Vanzacaftor Calcium | Tablet, Oral | Alyftrek | 2024 | 10 January 2043 |
| Hydromorphone Hydrochloride | Solution, Intramuscular, Intravenous, Subcutaneous | Hydromorphone Hydrochloride | 2023 | 10 January 2043 |
| Crinecerfont | Capsule, Oral | Crenessity | 2024 | 12 January 2043 |
| Crinecerfont | Solution, Oral | Crenessity | 2024 | 12 January 2043 |
| Dexmedetomidine Hydrochloride | Film, Buccal, Sublingual | Igalmi | 2022 | 12 January 2043 |
| Trofinetide | For Solution, Oral | Daybue Stix | 2025 | 12 January 2043 |
| Trofinetide | Solution, Oral | Daybue | 2023 | 12 January 2043 |
| Remibrutinib | Tablet, Oral | Rhapsido | 2025 | 19 January 2043 |
| Zanubrutinib | Tablet, Oral | Brukinsa | 2025 | 19 January 2043 |
| Deucravacitinib | Tablet, Oral | Sotyktu | 2022 | 11 February 2043 |
| Trabectedin | Solution, Intravenous | Evdi | 2026 | 18 February 2043 |
| Hydrocortisone | Solution, Oral | Khindivi | 2025 | 23 February 2043 |
| Atogepant | Tablet, Oral | Qulipta | 2021 | 27 February 2043 |
| Atrasentan Hydrochloride | Tablet, Oral | Vanrafia | 2025 | 25 March 2043 |
| Pralsetinib | Capsule, Oral | Gavreto | 2020 | 19 April 2043 |
| Nirogacestat Hydrobromide | Tablet, Oral | Ogsiveo | 2023 | 19 May 2043 |
| Vigabatrin | Solution, Oral | Vigafyde | 2024 | 8 June 2043 |
| Adagrasib | Tablet, Oral | Krazati | 2022 | 21 August 2043 |
| Abiraterone Acetate; Niraparib Tosylate | Tablet, Oral | Akeega | 2023 | 30 September 2043 |
| Drospirenone; Estetrol | Tablet, Oral | Nextstellis | 2021 | 1 October 2043 |
| Maralixibat Chloride | Tablet, Oral | Livmarli | 2025 | 5 October 2043 |
| Maribavir | Tablet, Oral | Livtencity | 2021 | 11 October 2043 |
| Corticotropin | Injectable, Injection | Acthar Gel, Acthar Gel (Autoinjector), Purified Cortrophin Gel | 2024 | 27 October 2043 |
| Sevabertinib | Tablet, Oral | Hyrnuo | 2025 | 14 November 2043 |
| Bupropion Hydrochloride; Dextromethorphan Hydrobromide | Tablet, Extended Release, Oral | Auvelity | 2022 | 28 November 2043 |
| Aminolevulinic Acid Hydrochloride | Gel, Topical | Ameluz | 2016 | 8 December 2043 |
| Hydrochlorothiazide | For Suspension, Oral | Inzirqo | 2025 | 23 January 2044 |
| Cabozantinib Laurylsulfate | Capsule, Oral | Omcazio | 2026 | 30 January 2044 |
| Artesunate | Powder, Intravenous | Artesunate | 2020 | 16 February 2044 |
| Elafibranor | Tablet, Oral | Iqirvo | 2024 | 5 March 2044 |
| Aceclidine Hydrochloride | Solution/Drops, Ophthalmic | Vizz | 2025 | 15 March 2044 |
| Paltusotine Hydrochloride | Tablet, Oral | Palsonify | 2025 | 25 March 2044 |
| Desmopressin Acetate | Solution, Oral | Desmoda | 2026 | 3 April 2044 |
| Milsaperidone | Tablet, Oral | Bysanti | 2026 | 31 May 2044 |
| Ensifentrine | Suspension, Inhalation | Ohtuvayre | 2024 | 25 June 2044 |
| Bupivacaine | Injectable, Liposomal, Injection | Exparel | 2011 | 2 July 2044 |
| Ziftomenib | Capsule, Oral | Komzifti | 2025 | 16 July 2044 |
| Iloprost | Solution, Intravenous | Aurlumyn | 2024 | 18 July 2044 |
| Mitomycin | Powder, Intravesical | Zusduri | 2025 | 25 July 2044 |
| Magnesium Sulfate; Polyethylene Glycol 3350; Potassium Chloride; Sodium Chloride; Sodium Sulfate | For Solution, Oral | Suflave | 2023 | 2 August 2044 |
| Levothyroxine Sodium | Capsule, Oral | Tirosint | 2006 | 26 September 2044 |
| Levothyroxine Sodium | Solution, Oral | Thyquidity, Tirosint-Sol | 2016 | 26 September 2044 |
| Methocarbamol | Suspension, Oral | Atmeksi | 2025 | 9 October 2044 |
| Deuruxolitinib Phosphate | Tablet, Oral | Leqselvi | 2024 | 10 October 2044 |
| Mirdametinib | Tablet, For Suspension, Oral | Gomekli | 2025 | 10 October 2044 |
| Mirdametinib | Capsule, Oral | Gomekli | 2025 | 10 October 2044 |
| Mometasone Furoate; Olopatadine Hydrochloride | Spray, Metered, Nasal | Ryaltris | 2022 | 21 November 2044 |
| Ponesimod | Tablet, Oral | Ponvory | 2021 | 24 December 2044 |
| Resmetirom | Tablet, Oral | Rezdiffra | 2024 | 4 February 2045 |
| Lamotrigine Hemifumarate | Suspension, Oral | Lamlique | 2026 | 14 February 2045 |
| Meloxicam; Rizatriptan Benzoate | Tablet, Oral | Symbravo | 2025 | 10 March 2045 |
| Carboplatin | Solution, Intravenous | Kyxata | 2025 | 1 April 2045 |
| Sirolimus | Gel, Topical | Hyftor | 2022 | 11 April 2045 |
| Vimseltinib | Capsule, Oral | Romvimza | 2025 | 30 April 2045 |
| Bumetanide | Spray, Nasal | Enbumyst | 2025 | 14 May 2045 |
| Elinzanetant | Capsule, Oral | Lynkuet | 2025 | 14 May 2045 |
| Pemetrexed Dipotassium | Powder, Intravenous | Axtle | 2024 | 25 June 2045 |
| Benzgalantamine Gluconate | Tablet, Delayed Release, Oral | Zunveyl | 2024 | 23 July 2045 |
| Clonidine Hydrochloride | Solution, Oral | Javadin, Qlonilik | 2025 | 22 August 2045 |
| Celecoxib | Suspension, Oral | Vyscoxa | 2025 | 17 September 2045 |
| Betamethasone Dipropionate | Spray, Topical | Sernivo | 2016 | 19 November 2045 |
| Acetic Acid, Glacial | Solution, Irrigation, Urethral | Acetic Acid 0.25% In Plastic Container | 1982 | none listed |
| Acetohydroxamic Acid | Tablet, Oral | Lithostat | 1983 | none listed |
| Acetylcholine Chloride | For Solution, Ophthalmic | Miochol-E | 1993 | none listed |
| Acyclovir; Hydrocortisone | Cream, Topical | Xerese | 2009 | none listed |
| Albuterol Sulfate | Powder, Metered, Inhalation | Proair Respiclick | 2015 | none listed |
| Albuterol Sulfate; Ipratropium Bromide | Spray, Metered, Inhalation | Combivent Respimat | 2011 | none listed |
| Alcohol; Chlorhexidine Gluconate | Solution, Topical | Avagard | 2001 | none listed |
| Alendronate Sodium; Cholecalciferol | Tablet, Oral | Fosamax Plus D | 2005 | none listed |
| Alfentanil Hydrochloride | Injectable, Injection | Alfenta | 1986 | none listed |
| Alitretinoin | Gel, Topical | Panretin | 1999 | none listed |
| Amifostine | Injectable, Injection | Ethyol | 1995 | none listed |
| Amino Acids; Calcium Chloride; Dextrose; Magnesium Chloride; Potassium Phosphate, Dibasic; Sodium Acetate; Sodium Chloride | Injectable, Injection | Clinimix E 2.75/10 Sulfite Free W/ Elect In Dextrose 10% W/ Calcium In Plastic Container, Clinimix E 2.75/25 Sulfite Free W/ Elect In Dextrose 25% W/ Calcium In Plastic Container, Clinimix E 2.75/5 Sulfite Free W/ Elect In Dextrose 5% W/ Calcium In Plastic Container | 1997 | none listed |
| Amino Acids; Dextrose | Injectable, Injection | Clinimix 2.75/10 Sulfite Free In Dextrose 10% In Plastic Container, Clinimix 2.75/25 Sulfite Free In Dextrose 25% In Plastic Container, Clinimix 2.75/5 Sulfite Free In Dextrose 5% In Plastic Container | 1984 | none listed |
| Aminolevulinic Acid Hydrochloride | For Solution, Oral | Gleolan | 2017 | none listed |
| Amlodipine Besylate | For Solution, Oral | Sdamlo | 2025 | none listed |
| Anidulafungin | Powder, Intravenous | Eraxis | 2006 | none listed |
| Argatroban | Solution, Intravenous | Argatroban In Sodium Chloride | 2011 | none listed |
| Arginine Hydrochloride | Injectable, Injection | R-Gene 10 | before 1982 | none listed |
| Artemether; Lumefantrine | Tablet, Oral | Coartem | 2009 | none listed |
| Articaine Hydrochloride; Epinephrine Bitartrate | Injectable, Injection | Orabloc, Septocaine | 2000 | none listed |
| Atazanavir Sulfate | Powder, Oral | Reyataz | 2014 | none listed |
| Atomoxetine Hydrochloride | Solution, Oral | Atoncy | 2026 | none listed |
| Atropine Sulfate; Difenoxin Hydrochloride | Tablet, Oral | Motofen | before 1982 | none listed |
| Atropine; Pralidoxime Chloride | Injectable, Intramuscular | Duodote | 2002 | none listed |
| Auranofin | Capsule, Oral | Ridaura | 1985 | none listed |
| Avobenzone; Ecamsule; Octocrylene | Cream, Topical | Anthelios Sx, Capital Soleil 15 | 2006 | none listed |
| Avobenzone; Ecamsule; Octocrylene; Titanium Dioxide | Cream, Topical | Anthelios 20, Anthelios 40 | 2006 | none listed |
| Azelaic Acid | Cream, Topical | Azelex | 1995 | none listed |
| Azithromycin | Solution/Drops, Ophthalmic | Azasite | 2007 | none listed |
| Aztreonam | For Solution, Inhalation | Cayston | 2010 | none listed |
| Barium Sulfate | Suspension, Oral | Entero Vu 24%, Liquid E-Z-Paque, Readi-Cat 2 | 2016 | none listed |
| Barium Sulfate | For Suspension, Oral | E-Z-Hd, E-Z-Paque, Varibar Thin Liquid | 2016 | none listed |
| Barium Sulfate | Paste, Oral | Varibar Pudding | 2016 | none listed |
| Barium Sulfate | Tablet, Oral | E-Z-Disk | 2025 | none listed |
| Bentoquatam | Lotion, Topical | Ivy Block | 1996 | none listed |
| Benznidazole | Tablet, Oral | Benznidazole | 2017 | none listed |
| Betaxolol Hydrochloride | Suspension/Drops, Ophthalmic | Betoptic S | 1989 | none listed |
| Bortezomib | Solution, Intravenous, Subcutaneous | Bortezomib | 2024 | none listed |
| Budesonide | Powder, Metered, Inhalation | Pulmicort Flexhaler | 1997 | none listed |
| Bupropion Hydrobromide | Tablet, Extended Release, Oral | Aplenzin | 2008 | none listed |
| Busulfan | Tablet, Oral | Myleran | before 1982 | none listed |
| Calcitriol | Ointment, Topical | Vectical | 2009 | none listed |
| Calcium Chloride; Dextrose; Glutathione Disulfide; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride; Sodium Phosphate | Solution, Irrigation | Bss Plus | 1999 | none listed |
| Calcium Chloride; Dextrose; Lactic Acid; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride | Injectable, Injection | Prismasol B22gk 4/0 In Plastic Container, Prismasol Bgk 0/2.5 In Plastic Container, Prismasol Bgk 2/0 In Plastic Container | 2006 | none listed |
| Calcium Chloride; Dextrose; Magnesium Chloride; Sodium Chloride; Sodium Lactate | Solution, Intraperitoneal | Delflex W/ Dextrose 1.5% In Plastic Container, Delflex W/ Dextrose 1.5% Low Magnesium In Plastic Container, Delflex W/ Dextrose 1.5% Low Magnesium Low Calcium In Plastic Container | 1982 | none listed |
| Calcium Chloride; Dextrose; Magnesium Sulfate; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride; Sodium Phosphate, Dibasic, Heptahydrate | Injectable, Intrathecal | Elliotts B Solution | 1996 | none listed |
| Calcium Chloride; Magnesium Chloride; Potassium Chloride; Sodium Acetate; Sodium Chloride | Injectable, Injection | Tpn Electrolytes In Plastic Container | 1984 | none listed |
| Calcium Chloride; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride; Sodium Phosphate | Injectable, Injection | Phoxillum B22k 4/0 In Plastic Container, Phoxillum Bk 4/2.5 In Plastic Container | 2015 | none listed |
| Calcium Chloride; Potassium Chloride; Sodium Chloride | Injectable, Injection | Ringer's In Plastic Container | 1982 | none listed |
| Calcium Chloride; Potassium Chloride; Sodium Chloride | Solution, Irrigation | Ringer's In Plastic Container | 1982 | none listed |
| Calcium Chloride; Potassium Chloride; Sodium Chloride; Sodium Lactate | Solution, Irrigation | Lactated Ringer's In Plastic Container | 1982 | none listed |
| Carbachol | Solution, Intraocular | Miostat | before 1982 | none listed |
| Carbidopa; Levodopa | Suspension, Enteral | Duopa | 2015 | none listed |
| Carmustine | Implant, Intracranial | Gliadel | 1996 | none listed |
| Cefazolin Sodium | Powder, Intravenous | Cefazolin Sodium | 2022 | none listed |
| Cefazolin Sodium | Solution, Intravenous | Cefazolin In Dextrose | 2015 | none listed |
| Cefotaxime Sodium | Injectable, Injection | Claforan | 1983 | none listed |
| Chlorambucil | Tablet, Oral | Leukeran | before 1982 | none listed |
| Chlorhexidine Gluconate | Solution, Topical | Chg Scrub, Chlorhexidine Gluconate, Cida-Stat | 1984 | none listed |
| Chlorhexidine Gluconate | Aerosol, Metered, Topical | Exidine | 1984 | none listed |
| Chlorhexidine Gluconate; Isopropyl Alcohol | Swab, Topical | Chloraprep One-Step Sepp, Chloraprep Single Swabstick, Chloraprep Triple Swabstick | 2002 | none listed |
| Chlorhexidine Gluconate; Isopropyl Alcohol | Solution, Topical | Soluprep S | 2018 | none listed |
| Chlorpheniramine Maleate; Ibuprofen; Phenylephrine Hydrochloride | Tablet, Oral | Advil Allergy And Congestion Relief, Advil Multi-Symptom Cold & Flu | 2011 | none listed |
| Chlorpheniramine Maleate; Ibuprofen; Pseudoephedrine Hydrochloride | Suspension, Oral | Children's Advil Allergy Sinus | 2004 | none listed |
| Cholic Acid | Capsule, Oral | Cholbam | 2015 | none listed |
| Ciprofloxacin Hydrochloride | Ointment, Ophthalmic | Ciloxan | 1998 | none listed |
| Citric Acid; Gluconolactone; Magnesium Carbonate | Solution, Irrigation | Renacidin | 1990 | none listed |
| Citric Acid; Urea C-13 | For Solution, Tablet, For Solution, Oral | Idkit:hp | 2002 | none listed |
| Clindamycin Phosphate | Solution, Intravenous | Clindamycin Phosphate In 0.9% Sodium Chloride | 2017 | none listed |
| Clindamycin Phosphate | Suppository, Vaginal | Cleocin | 1999 | none listed |
| Cobicistat; Darunavir Ethanolate | Tablet, For Suspension, Oral | Prezcobix Ped | 2026 | none listed |
| Colestipol Hydrochloride | Granule, Oral | Colestid | 1995 | none listed |
| Colistin Sulfate; Hydrocortisone Acetate; Neomycin Sulfate; Thonzonium Bromide | Suspension/Drops, Otic | Coly-Mycin S | before 1982 | none listed |
| Conivaptan Hydrochloride | Injectable, Intravenous | Vaprisol In 5% Dextrose In Plastic Container | 2005 | none listed |
| Crotamiton | Cream, Topical | Eurax | before 1982 | none listed |
| Cyclophosphamide | Tablet, Oral | Cytoxan | before 1982 | none listed |
| Cysteamine Bitartrate | Capsule, Oral | Cystagon | 1994 | none listed |
| Cysteamine Hydrochloride | Solution/Drops, Ophthalmic | Cystadrops, Cystaran | 2012 | none listed |
| Dabigatran Etexilate Mesylate | Pellets, Oral | Pradaxa | 2021 | none listed |
| Dalteparin Sodium | Injectable, Subcutaneous | Fragmin | 1994 | none listed |
| Dantrolene Sodium | For Suspension, Intravenous | Ryanodex | 2014 | none listed |
| Daptomycin | Solution, Intravenous | Daptomycin In 0.9% Sodium Chloride | 2023 | none listed |
| Desvenlafaxine | Tablet, Extended Release, Oral | Desvenlafaxine | 2013 | none listed |
| Dexamethasone | Suspension/Drops, Ophthalmic | Maxidex | before 1982 | none listed |
| Dexamethasone | Implant, Intravitreal | Ozurdex | 2009 | none listed |
| Dexamethasone; Tobramycin | Ointment, Ophthalmic | Tobradex | 1988 | none listed |
| Dextrose; Magnesium Acetate; Potassium Acetate; Sodium Chloride | Injectable, Injection | Normosol-M And Dextrose 5% In Plastic Container | before 1982 | none listed |
| Dextrose; Magnesium Chloride; Potassium Chloride; Potassium Phosphate, Dibasic; Sodium Acetate | Injectable, Injection | Isolyte P In Dextrose 5% In Plastic Container | 1984 | none listed |
| Dextrose; Magnesium Chloride; Potassium Chloride; Potassium Phosphate, Monobasic; Sodium Chloride; Sodium Lactate | Injectable, Injection | Dextrose 5% And Electrolyte No. 48 In Plastic Container | before 1982 | none listed |
| Dextrose; Magnesium Chloride; Potassium Chloride; Potassium Phosphate, Monobasic; Sodium Lactate; Sodium Phosphate, Monobasic Anhydrous | Injectable, Injection | Ionosol Mb And Dextrose 5% In Plastic Container | 1986 | none listed |
| Dextrose; Magnesium Chloride; Potassium Chloride; Sodium Acetate; Sodium Chloride; Sodium Gluconate | Injectable, Injection | Normosol-R And Dextrose 5% In Plastic Container | 1993 | none listed |
| Diatrizoate Meglumine | Solution, Urethral | Cystografin, Cystografin Dilute | 1982 | none listed |
| Diclofenac Sodium | Solution, Intravenous | Zueino | 2014 | none listed |
| Diltiazem Hydrochloride | Solution, Intravenous | Diltiazem Hydrochloride In 0.72% Sodium Chloride | 2021 | none listed |
| Dimercaprol | Injectable, Injection | Bal | before 1982 | none listed |
| Dinoprostone | Gel, Endocervical | Prepidil | 1992 | none listed |
| Dinoprostone | Insert, Extended Release, Vaginal | Cervidil | 1995 | none listed |
| Dobutamine Hydrochloride | Solution, Intravenous | Dobutamine Hydrochloride In Dextrose 5% In Plastic Container | 1993 | none listed |
| Doxazosin Mesylate | Tablet, Extended Release, Oral | Cardura Xl | 2005 | none listed |
| Echothiophate Iodide | For Solution, Ophthalmic | Phospholine Iodide | before 1982 | none listed |
| Emtricitabine | Solution, Oral | Emtriva | 2005 | none listed |
| Entecavir | Solution, Oral | Baraclude | 2005 | none listed |
| Epinephrine | Aerosol, Metered, Inhalation | Primatene Mist | 2018 | none listed |
| Epinephrine Bitartrate | Solution, Intravenous | Epinephrine Bitartrate In 0.9% Sodium Chloride | 2025 | none listed |
| Epinephrine Bitartrate; Lidocaine Hydrochloride | Solution, Injection | Flavalta | 2026 | none listed |
| Escitalopram Oxalate | Capsule, Oral | Escitalopram | 2025 | none listed |
| Estradiol | Insert, Extended Release, Vaginal | Estring | 1996 | none listed |
| Estradiol | Spray, Transdermal | Evamist | 2007 | none listed |
| Estradiol Acetate | Insert, Extended Release, Vaginal | Femring | 2003 | none listed |
| Estradiol; Levonorgestrel | Film, Extended Release, Transdermal | Climara Pro | 2003 | none listed |
| Estradiol; Norethindrone Acetate | Film, Extended Release, Transdermal | Combipatch | 1998 | none listed |
| Estrogens, Conjugated | Cream, Topical, Vaginal | Premarin | before 1982 | none listed |
| Estrogens, Conjugated | Injectable, Injection | Premarin | before 1982 | none listed |
| Estrogens, Conjugated; Medroxyprogesterone Acetate | Tablet, Oral-28 | Premphase 14/14, Prempro | 1994 | none listed |
| Ethanolamine Oleate | Injectable, Injection | Ethamolin | 1988 | none listed |
| Ethiodized Oil | Oil, Intralymphatic, Intrauterine | Lipiodol | before 1982 | none listed |
| Etoposide | Solution, Intravenous | Avopef | 2026 | none listed |
| Etoposide Phosphate | Injectable, Injection | Etopophos Preservative Free | 1996 | none listed |
| Famotidine | Tablet, Chewable, Oral | Pepcid Ac | 1998 | none listed |
| Ferric Hexacyanoferrate(Ii) | Capsule, Oral | Radiogardase (Prussian Blue) | 2003 | none listed |
| Fish Oil Triglycerides | Emulsion, Intravenous | Omegaven | 2018 | none listed |
| Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil | Emulsion, Intravenous | Smoflipid 20% | 2016 | none listed |
| Fluocinolone Acetonide; Hydroquinone; Tretinoin | Cream, Topical | Tri-Luma | 2002 | none listed |
| Fluorodopa F-18 | Solution, Intravenous | Fluorodopa F18 | 2019 | none listed |
| Fluoroestradiol F-18 | Solution, Intravenous | Cerianna | 2020 | none listed |
| Fluorometholone Acetate | Suspension/Drops, Ophthalmic | Flarex | 1986 | none listed |
| Fluorouracil | Solution, Intravenous | Favlyxa | 2026 | none listed |
| Flurandrenolide | Tape, Topical | Cordran | before 1982 | none listed |
| Fluticasone Furoate | Powder, Inhalation | Arnuity Ellipta | 2014 | none listed |
| Fluticasone Propionate | Powder, Inhalation | Flovent Diskus 100, Flovent Diskus 250, Flovent Diskus 50 | 1997 | none listed |
| Fluticasone Propionate; Salmeterol Xinafoate | Aerosol, Metered, Inhalation | Advair Hfa | 2006 | none listed |
| Folic Acid | Solution, Oral | Quiofic | 2026 | none listed |
| Formoterol Fumarate; Mometasone Furoate | Aerosol, Metered, Inhalation | Dulera | 2010 | none listed |
| Gadobenate Dimeglumine | Injectable, Intravenous | Multihance, Multihance Multipack | 2004 | none listed |
| Gadodiamide | Injectable, Injection | Omniscan | 1993 | none listed |
| Gadoxetate Disodium | Solution, Intravenous | Eovist | 2008 | none listed |
| Gallium Citrate Ga-67 | Injectable, Injection | Gallium Citrate Ga 67 | before 1982 | none listed |
| Ganciclovir | Gel, Ophthalmic | Zirgan | 2009 | none listed |
| Gemcitabine Hydrochloride | Solution, Intravenous | Avgemsi | 2017 | none listed |
| Glucagon Hydrochloride | Powder, Intramuscular, Intravenous | Glucagon | 1998 | none listed |
| Glucagon Hydrochloride | Powder, Intramuscular, Intravenous, Subcutaneous | Glucagon | 1998 | none listed |
| Glycine | Solution, Irrigation | Aminoacetic Acid 1.5% In Plastic Container, Glycine 1.5% In Plastic Container | 1982 | none listed |
| Glycopyrrolate | Solution, Intramuscular, Intravenous | Glycopyrrolate, Glyrx-Pf | 2018 | none listed |
| Goserelin Acetate | Implant, Implantation | Zoladex | 1989 | none listed |
| Granisetron | Film, Extended Release, Transdermal | Sancuso | 2008 | none listed |
| Hexachlorophene | Sponge, Topical | Pre-Op, Pre-Op Ii | before 1982 | none listed |
| Histrelin Acetate | Implant, Subcutaneous | Supprelin La | 2004 | none listed |
| Hydrocortisone Acetate | Aerosol, Metered, Rectal | Cortifoam | 1982 | none listed |
| Hydroxyurea | Tablet, Oral | Siklos | 2017 | none listed |
| Ibuprofen Sodium | Tablet, Oral | Advil | 2012 | none listed |
| Ibuprofen; Pseudoephedrine Hydrochloride | Suspension, Oral | Children's Advil Cold, Children's Motrin Cold | 2000 | none listed |
| Icodextrin | Solution, Intraperitoneal | Extraneal | 2002 | none listed |
| Indium In-111 Pentetate Disodium | Injectable, Intrathecal | Mpi Indium Dtpa In 111 | 1982 | none listed |
| Indium In-111 Pentetreotide Kit | Injectable, Injection | Octreoscan | 1994 | none listed |
| Indocyanine Green | Solution, Intravenous, Interstitial | Zyogreen | 2026 | none listed |
| Indomethacin | Injectable, Injection | Indomethacin | 2010 | none listed |
| Iobenguane Sulfate I-123 | Solution, Intravenous | Adreview | 2008 | none listed |
| Iodine Povacrylex; Isopropyl Alcohol | Sponge, Topical | Duraprep | 2006 | none listed |
| Iohexol | Injectable, Injection | Omnipaque 140 | 1988 | none listed |
| Iohexol | Solution, Oral | Omnipaque 12, Omnipaque 9 | 2018 | none listed |
| Iopromide | Injectable, Injection | Ultravist (Pharmacy Bulk), Ultravist 300, Ultravist 370 | 1995 | none listed |
| Iothalamate Meglumine | Solution, Intravesical | Cysto-Conray Ii | before 1982 | none listed |
| Iothalamate Sodium I-125 | Injectable, Injection | Glofil-125 | before 1982 | none listed |
| Ioversol | Injectable, Injection | Optiray 300, Optiray 320, Optiray 350 | 1988 | none listed |
| Iron Dextran | Injectable, Injection | Infed | 1996 | none listed |
| Isocarboxazid | Tablet, Oral | Marplan | before 1982 | none listed |
| Ixabepilone | Injectable, Intravenous | Ixempra Kit | 2007 | none listed |
| Ketorolac Tromethamine | Spray, Metered, Nasal | Sprix | 2010 | none listed |
| Labetalol Hydrochloride | Solution, Intravenous | Labetalol Hydrochloride, Labetalol Hydrochloride In Dextrose, Labetalol Hydrochloride In Sodium Chloride | 2020 | none listed |
| Lamivudine; Tenofovir Disoproxil Fumarate | Tablet, Oral | Cimduo | 2018 | none listed |
| Leuprolide Acetate | For Suspension, Intramuscular | Leuprolide Acetate For Depot Suspension | 2018 | none listed |
| Levalbuterol Tartrate | Aerosol, Metered, Inhalation | Xopenex Hfa | 2005 | none listed |
| Lidocaine Hydrochloride | Gel, Ophthalmic | Akten | 2008 | none listed |
| Lidocaine; Prilocaine | Gel, Periodontal | Oraqix | 2003 | none listed |
| Lirafugratinib Hydrochloride | Capsule, Oral | Lyrfigtu | 2026 | none listed |
| Lithium Carbonate | Tablet, Oral | Lithium Carbonate | 1982 | none listed |
| Lopinavir; Ritonavir | Solution, Oral | Kaletra | 2000 | none listed |
| Loteprednol Etabonate | Ointment, Ophthalmic | Lotemax | 2011 | none listed |
| Loxapine | Powder, Inhalation | Adasuve | 2012 | none listed |
| Mafenide Acetate | Cream, Topical | Sulfamylon | before 1982 | none listed |
| Magnesium Chloride; Potassium Chloride; Potassium Phosphate, Monobasic; Sodium Acetate; Sodium Chloride; Sodium Gluconate; Sodium Phosphate, Dibasic, Heptahydrate | Injectable, Injection | Isolyte S Ph 7.4 In Plastic Container | 1984 | none listed |
| Magnesium Chloride; Potassium Chloride; Sodium Acetate; Sodium Chloride; Sodium Gluconate | Solution, Irrigation | Physiolyte In Plastic Container, Physiosol In Plastic Container | 1982 | none listed |
| Magnesium Chloride; Sodium Bicarbonate; Sodium Chloride | Solution, Injection | Normocarb Hf 25, Normocarb Hf 35 | 2006 | none listed |
| Magnesium Sulfate; Potassium Chloride; Potassium Phosphate, Monobasic; Sodium Chloride; Sodium Phosphate | Solution, Irrigation | Tis-U-Sol, Tis-U-Sol In Plastic Container | 1982 | none listed |
| Mannitol; Sorbitol | Solution, Irrigation | Sorbitol-Mannitol In Plastic Container | before 1982 | none listed |
| Maraviroc | Solution, Oral | Selzentry | 2016 | none listed |
| Meclizine Hydrochloride | Tablet, Chewable, Oral | Antivert | before 1982 | none listed |
| Medroxyprogesterone Acetate | Injectable, Subcutaneous | Depo-Subq Provera 104 | 2004 | none listed |
| Meloxicam | Suspension, Oral | Meloxicam | 2004 | none listed |
| Metformin Hydrochloride; Sitagliptin | Tablet, Extended Release, Oral | Zituvimet Xr | 2024 | none listed |
| Metformin Hydrochloride; Sitagliptin | Tablet, Oral | Zituvimet | 2023 | none listed |
| Methacholine Chloride | For Solution, Inhalation | Provocholine | 1986 | none listed |
| Methoxsalen | Injectable, Injection | Uvadex | 1999 | none listed |
| Metoprolol Tartrate | Solution, Oral | Lopressor | 2025 | none listed |
| Metyrapone | Capsule, Oral | Metopirone | 1996 | none listed |
| Miconazole | Tablet, Buccal | Oravig | 2010 | none listed |
| Midazolam Hydrochloride | Solution, Intramuscular | Midazolam Hydrochloride (Autoinjector) | 2018 | none listed |
| Miltefosine | Capsule, Oral | Impavido | 2014 | none listed |
| Minocycline Hydrochloride | Powder, Extended Release, Dental | Arestin | 2001 | none listed |
| Mitotane | Tablet, Oral | Lysodren | before 1982 | none listed |
| Mometasone Furoate | Aerosol, Metered, Inhalation | Asmanex Hfa | 2014 | none listed |
| Mometasone Furoate | Powder, Inhalation | Asmanex Twisthaler | 2005 | none listed |
| Nafarelin Acetate | Spray, Metered, Nasal | Synarel | 1990 | none listed |
| Natamycin | Suspension, Ophthalmic | Natacyn | before 1982 | none listed |
| Nelfinavir Mesylate | Tablet, Oral | Viracept | 1997 | none listed |
| Nicotine | Spray, Metered, Nasal | Nicotrol | 1996 | none listed |
| Nitroglycerin | Aerosol, Metered, Sublingual | Nitromist | 2006 | none listed |
| Nizatidine | Tablet, Oral | Axid Ar | 1996 | none listed |
| Norgestrel | Tablet, Oral | Opill | before 1982 | none listed |
| Olanzapine Pamoate | Suspension, Extended Release, Intramuscular | Zyprexa Relprevv | 2009 | none listed |
| Olsalazine Sodium | Capsule, Oral | Dipentum | 1990 | none listed |
| Omeprazole Magnesium | For Suspension, Delayed Release, Oral | Prilosec | 2008 | none listed |
| Orlistat | Capsule, Oral | Alli, Xenical | 1999 | none listed |
| Oxaprozin | Capsule, Oral | Coxanto | 2023 | none listed |
| Oxybutynin | Film, Extended Release, Transdermal | Oxytrol, Oxytrol For Women | 2003 | none listed |
| Palonosetron Hydrochloride | Solution, Intravenous | Posfrea | 2016 | none listed |
| Pantoprazole Sodium | Solution, Intravenous | Pantoprazole Sodium In 0.9% Sodium Chloride | 2024 | none listed |
| Penicillin G Benzathine | Injectable, Injection | Bicillin L-A | before 1982 | none listed |
| Penicillin G Benzathine; Penicillin G Procaine | Injectable, Injection | Bicillin C-R, Bicillin C-R 900/300 | before 1982 | none listed |
| Pentosan Polysulfate Sodium | Capsule, Oral | Elmiron | 1996 | none listed |
| Phendimetrazine Tartrate | Capsule, Extended Release, Oral | Phendimetrazine Tartrate | before 1982 | none listed |
| Piperacillin Sodium; Tazobactam Sodium | Powder, Intravenous | Piperacillin And Tazobactam And Sodium Chloride In Duplex Container | 2025 | none listed |
| Pivmecillinam Hydrochloride | Tablet, Oral | Pivya | 2024 | none listed |
| Porfimer Sodium | Injectable, Injection | Photofrin | 1995 | none listed |
| Povidone-Iodine | Solution, Topical | Povidone Iodine | 1989 | none listed |
| Povidone-Iodine | Solution/Drops, Ophthalmic | Betadine | 1986 | none listed |
| Pralidoxime Chloride | Injectable, Injection | Protopam Chloride | 1982 | none listed |
| Prednisolone Sodium Phosphate | Tablet, Orally Disintegrating, Oral | Orapred Odt | 2006 | none listed |
| Procarbazine Hydrochloride | Capsule, Oral | Matulane | before 1982 | none listed |
| Progesterone | Gel, Vaginal | Crinone | 1997 | none listed |
| Purified Water | Solution, Ophthalmic | Pur-Wash | 2011 | none listed |
| Pyridostigmine Bromide | Injectable, Injection | Mestinon, Regonol | before 1982 | none listed |
| Radium Ra-223 Dichloride | Solution, Intravenous | Xofigo | 2013 | none listed |
| Ritonavir | Powder, Oral | Norvir | 2017 | none listed |
| Rubidium Chloride Rb-82 | Injectable, Injection | Cardiogen-82 | 1989 | none listed |
| Rubidium Chloride Rb-82 | Solution, Intravenous | Ruby-Fill | 2016 | none listed |
| Salmeterol Xinafoate | Powder, Inhalation | Serevent | 1997 | none listed |
| Secretin Synthetic Human | For Solution, Intravenous | Chirhostim | 2004 | none listed |
| Selegiline | Film, Extended Release, Transdermal | Emsam | 2006 | none listed |
| Sertaconazole Nitrate | Cream, Topical | Ertaczo | 2003 | none listed |
| Silver Sulfadiazine | Cream, Topical | Silvadene, Ssd, Thermazene | 1982 | none listed |
| Sinecatechins | Ointment, Topical | Veregen | 2006 | none listed |
| Sodium Chloride | Solution For Slush, Irrigation | Sodium Chloride 0.9% In Sterile Plastic Container | 1985 | none listed |
| Sodium Glycerophosphate | Solution, Intravenous | Glycophos | 2026 | none listed |
| Sodium Iodide I-131 | Capsule, Oral | Sodium Iodide I 131 | 2004 | none listed |
| Sodium Phenylbutyrate | Pellets, Oral | Pheburane | 2022 | none listed |
| Sorbitol | Solution, Irrigation | Sorbitol 3% In Plastic Container, Sorbitol 3.3% In Plastic Container | 1982 | none listed |
| Soybean Oil | Injectable, Injection | Intralipid 20%, Intralipid 30%, Nutrilipid 20% | 1982 | none listed |
| Succimer | Capsule, Oral | Chemet | 1991 | none listed |
| Sulconazole Nitrate | Cream, Topical | Exelderm | 1989 | none listed |
| Talc | Powder, Intrapleural | Steritalc, Talc | 2003 | none listed |
| Talc | Aerosol, Intrapleural | Sclerosol | 1997 | none listed |
| Tamoxifen Citrate | Solution, Oral | Soltamox | 2005 | none listed |
| Tavapadon | Tablet, Oral | Juvmo, Juvmo (Copackaged) | 2026 | none listed |
| Technetium Tc-99m Bicisate Kit | Injectable, Injection | Neurolite | 1994 | none listed |
| Technetium Tc-99m Exametazime Kit | Injectable, Injection | Ceretec | 1988 | none listed |
| Technetium Tc-99m Exametazime Kit | Powder, Intravenous | Drax Exametazime | 2017 | none listed |
| Technetium Tc-99m Medronate | Injectable, Injection | Draximage Mdp-25 | 2004 | none listed |
| Technetium Tc-99m Medronate Kit | Injectable, Injection | Cis-Mdp, Technetium Tc-99m Medronate Kit | 1982 | none listed |
| Technetium Tc-99m Mertiatide Kit | Powder, Intravenous | Technetium Tc 99m Mertiatide Kit | 2023 | none listed |
| Technetium Tc-99m Oxidronate Kit | Injectable, Injection | Technescan Hdp | before 1982 | none listed |
| Technetium Tc-99m Pyrophosphate Kit | Injectable, Injection | Cis-Pyro, Technescan Pyp Kit | 1987 | none listed |
| Technetium Tc-99m Red Blood Cell Kit | Injectable, Injection | Ultratag | 1991 | none listed |
| Technetium Tc-99m Sodium Pertechnetate Generator | Solution, Intravenous | Technelite, Ultra-Technekow V4 | 2014 | none listed |
| Technetium Tc-99m Succimer | Powder, Intravenous | Nephroscan | 2022 | none listed |
| Teduglutide | Powder, Subcutaneous | Gattex Kit | 2012 | none listed |
| Temozolomide | Powder, Intravenous | Temodar | 2009 | none listed |
| Tenofovir Disoproxil Fumarate | Powder, Oral | Viread | 2012 | none listed |
| Terbinafine | Gel, Topical | Lamisil At | 1998 | none listed |
| Terbinafine Hydrochloride | Solution, Topical | Lamisil At | 1997 | none listed |
| Terbinafine Hydrochloride | Spray, Topical | Lamisil At | 2000 | none listed |
| Thallous Chloride Tl-201 | Injectable, Injection | Thallous Chloride Tl 201 | 1982 | none listed |
| Thioguanine | Tablet, Oral | Thioguanine | before 1982 | none listed |
| Tipranavir | Capsule, Oral | Aptivus | 2005 | none listed |
| Tiratricol | Tablet, For Suspension, Oral | Emcitate | 2026 | none listed |
| Tirofiban Hydrochloride | Solution, Injection | Aggrastat | 2016 | none listed |
| Tobramycin | Ointment, Ophthalmic | Tobrex | before 1982 | none listed |
| Topotecan Hydrochloride | Capsule, Oral | Hycamtin | 2007 | none listed |
| Tramadol Hydrochloride | Capsule, Extended Release, Oral | Conzip | 2010 | none listed |
| Triclabendazole | Tablet, Oral | Egaten | 2019 | none listed |
| Trypan Blue | Solution, Ophthalmic | Visionblue | 2004 | none listed |
| Vancomycin Hydrochloride | Powder, Intravenous, Oral | Vancomycin Hydrochloride | 2023 | none listed |
| Verteporfin | Injectable, Injection | Visudyne | 2000 | none listed |
| Vitamin A Palmitate | Injectable, Injection | Aquasol A | before 1982 | none listed |
| Xenon Xe-133 | Gas, Inhalation | Xenon Xe 133 | 1982 | none listed |
| Zanamivir | Powder, Inhalation | Relenza | 1999 | none listed |
| Ziconotide Acetate | Injectable, Intrathecal | Prialt | 2004 | none listed |
| Zidovudine | Injectable, Injection | Retrovir | 1990 | none listed |
| Zilurgisertib Fumarate | Tablet, Oral | Atebrioz | 2026 | none listed |
| Zinc Acetate | Capsule, Oral | Galzin | 1997 | none listed |
From the FDA Orange Book data files downloaded 12 November 2026. "Marketed" means not listed as discontinued. Biologics are not in the Orange Book.
How was this list built?
The list holds every ingredient and dosage-form group with a brand product listed as marketed and no generic product listed as marketed, under a method written before any count was published. See the FDA Orange Book, how generic drugs are approved, patent certifications for generic applications, 21 CFR Part 314, 21 USC 355 and the FDA first generic approvals.
Questions
Does a brand with no generic mean a generic is coming?
No. The list shows what the Orange Book records today. It does not say a generic has been filed or approved, and a listed date is not a launch date.
Why is there no generic for some of these?
The data does not say. A patent or exclusivity may be listed, no company may have filed, or the product may be hard to copy. The list reports the listing and does not guess the reason.
Is a medicine on this list in shortage?
Not by itself. This list says nothing about supply. The FDA keeps a separate drug shortage list, and the OmniRx shortage outlook shows how long each listing has run.