Generic competition · all medicines · read 12 November 2026

Is there a generic of Oxymetazoline Hydrochloride, and who makes it?

Oxymetazoline Hydrochloride appears in 2 dosage-form groups in the FDA Orange Book as of 12 November 2026, with 1 generic maker listed as marketed across them. 1 group has a brand listed as marketed and no generic listed as marketed. The data does not state why, and it does not state that one is coming. Where both are dated, the first generic approval came 4.7 years after the first brand approval. This is the Orange Book's listing, not a forecast.

Compiled and checked by Vincent Wesley Couey (ORCID 0009-0005-6869-308X) from the Orange Book data files, downloaded 12 November 2026.

Not medical advice. This page reports what the FDA's Orange Book lists, not what a pharmacy has in stock, what anything costs, or whether a generic is right for you. Ask your pharmacist or prescriber about your own medicine.

Oxymetazoline Hydrochloride2 dosage-form groups in the Orange Book

1generic maker listed

Oxymetazoline Hydrochloride appears in 2 dosage-form groups in the FDA Orange Book as of 12 November 2026, with 1 generic maker listed as marketed across them.
1 group has a brand listed as marketed and no generic listed as marketed. The data does not state why, and it does not state that one is coming.
Where both are dated, the first generic approval came 4.7 years after the first brand approval.
Patents and exclusivities are shown as listed by the application holder; the Orange Book does not rule on them, and a listed patent is not a statement that a generic is blocked. This says nothing about price, supply or quality.

Solution/Drops, Ophthalmic

Brand listed, no generic listed as marketed

Brand listed as marketed: Upneeq and Visine L.r.. No generic is listed as marketed.

generic makers listed as marketed, by first approvallisted patent expiryexclusivity end

Patents and exclusivities still listed

26 August 2031Patent 8357714
26 August 2031Patent 9867808
26 August 2031Patent 10912765
16 December 2039Patent 11324722
16 December 2039Patent 10940138
16 December 2039Patent 10799481
16 December 2039Patent 11701343
16 December 2039Patent 12648930

6 more patents are listed.

Cream, Topical

One to three generic makers listed

Brand listed as marketed: Rhofade. 1 generic maker with 1 generic product listed as marketed; the first generic approval is dated 4 October 2021.

generic makers listed as marketed, by first approvallisted patent expiryexclusivity end

Generic maker (applicant)	First approval	Products
Sun Pharma Canada Inc	4 October 2021	1

Patents and exclusivities still listed

2 May 2028Patent 7812049
1 December 2031Patent 8883838 drug product
11 June 2035Patent 9974773
11 June 2035Patent 10751325
11 June 2035Patent 12350255
11 June 2035Patent 10335391
11 June 2035Patent 11517560

US Food and Drug Administration, Orange Book data files, downloaded 12 November 2026. A listed patent is not a ruling that a generic is blocked, and no figure here says anything about price, supply or quality. Check the Orange Book.

Where can you go from this result?

Open it in the check to search another medicine, or see every brand with no generic listed. The FDA explains generic approval in how generic drugs are approved and the FDA generic drug facts, and the Orange Book itself is the FDA Orange Book. To check what is available now, ask your pharmacist, and see the FDA drug shortages page.