Generic competition · all medicines · read 12 November 2026
Is there a generic of Clobetasol Propionate, and who makes it?
Clobetasol Propionate appears in 9 dosage-form groups in the FDA Orange Book as of 12 November 2026, with 23 generic makers listed as marketed across them. 1 group has a brand listed as marketed and no generic listed as marketed. The data does not state why, and it does not state that one is coming. Where both are dated, the first generic approval came between 3.5 and 8.1 years after the first brand approval. This is the Orange Book's listing, not a forecast.
Compiled and checked by Vincent Wesley Couey (ORCID 0009-0005-6869-308X) from the Orange Book data files, downloaded 12 November 2026.
- Clobetasol Propionate appears in 9 dosage-form groups in the FDA Orange Book as of 12 November 2026, with 23 generic makers listed as marketed across them.
- 1 group has a brand listed as marketed and no generic listed as marketed. The data does not state why, and it does not state that one is coming.
- Where both are dated, the first generic approval came between 3.5 and 8.1 years after the first brand approval.
- Patents and exclusivities are shown as listed by the application holder; the Orange Book does not rule on them, and a listed patent is not a statement that a generic is blocked. This says nothing about price, supply or quality.
Cream, Topical
Four or more generic makers listed
Brand listed as marketed: Impoyz. 11 generic makers with 13 generic products listed as marketed; the first generic approval is dated 16 February 1994.
| Generic maker (applicant) | First approval | Products |
|---|---|---|
| Sun Pharma Canada Inc | 8 July 1996 | 2 |
| Fougera Pharmaceuticals Inc | 30 September 1996 | 2 |
| Aurobindo Pharma Usa Inc | 9 February 2001 | 1 |
| Beach Products Inc | 21 August 2017 | 1 |
| Lupin Ltd | 30 January 2018 | 1 |
| Xiromed Pharma Espana Sl | 15 June 2018 | 1 |
| Zydus Pharmaceuticals Usa Inc | 15 October 2018 | 1 |
| Rising Pharma Holdings Inc | 11 January 2019 | 1 |
| Torrent Pharmaceuticals Ltd | 30 December 2019 | 1 |
| Alembic Pharmaceuticals Ltd | 27 January 2020 | 1 |
| Encube Ethicals Private Ltd | 28 August 2020 | 1 |
Patents and exclusivities still listed
- 31 August 2030Patent 10064875 drug product
- 31 August 2030Patent 9956231 drug product
- 31 August 2030Patent 11179465 drug product
- 31 August 2030Patent 10588914 drug product
- 11 March 2035Patent 9855334 drug product
Ointment, Topical
Four or more generic makers listed
Every brand product here is listed as discontinued. 10 generic makers with 10 generic products listed as marketed; the first generic approval is dated 16 February 1994.
| Generic maker (applicant) | First approval | Products |
|---|---|---|
| Cosette Pharmaceuticals Nc Laboratories Llc | 16 February 1994 | 1 |
| Fougera Pharmaceuticals Inc | 23 February 1996 | 1 |
| Sun Pharma Canada Inc | 12 July 1996 | 1 |
| Aurobindo Pharma Usa Inc | 12 August 1998 | 1 |
| Zydus Pharmaceuticals Usa Inc | 27 October 2017 | 1 |
| Xiromed Pharma Espana Sl | 17 April 2018 | 1 |
| Novel Laboratories Inc | 4 May 2018 | 1 |
| Alembic Pharmaceuticals Ltd | 4 March 2019 | 1 |
| Encube Ethicals Private Ltd | 15 November 2019 | 1 |
| Macleods Pharmaceuticals Ltd | 28 December 2023 | 1 |
Patents and exclusivities still listed
No unexpired patent or exclusivity is listed against the marketed brand products in this group.
Solution, Topical
Four or more generic makers listed
Every brand product here is listed as discontinued. 8 generic makers with 8 generic products listed as marketed; the first generic approval is dated 6 December 1995.
| Generic maker (applicant) | First approval | Products |
|---|---|---|
| Sun Pharma Canada Inc | 16 November 1998 | 1 |
| Fougera Pharmaceuticals Inc | 8 February 1999 | 1 |
| Encube Ethicals Private Ltd | 5 August 2005 | 1 |
| Novel Laboratories Inc | 23 November 2015 | 1 |
| Macleods Pharmaceuticals Ltd | 25 October 2017 | 1 |
| Saptalis Pharmaceuticals Llc | 2 October 2019 | 1 |
| Alembic Pharmaceuticals Ltd | 21 October 2019 | 1 |
| Quagen Pharmaceuticals Llc | 17 February 2022 | 1 |
Patents and exclusivities still listed
No unexpired patent or exclusivity is listed against the marketed brand products in this group.
Aerosol, Foam, Topical
Four or more generic makers listed
Every brand product here is listed as discontinued. 5 generic makers with 7 generic products listed as marketed; the first generic approval is dated 10 March 2008.
| Generic maker (applicant) | First approval | Products |
|---|---|---|
| Padagis Israel Pharmaceuticals Ltd | 10 March 2008 | 2 |
| Taro Pharmaceutical Industries Ltd | 4 October 2018 | 1 |
| Glenmark Pharmaceuticals Ltd | 15 February 2019 | 2 |
| Alembic Pharmaceuticals Ltd | 21 April 2022 | 1 |
| Xiromed Pharma Espana Sl | 20 November 2025 | 1 |
Patents and exclusivities still listed
No unexpired patent or exclusivity is listed against the marketed brand products in this group.
Spray, Topical
One to three generic makers listed
Brand listed as marketed: Clobex. 3 generic makers with 3 generic products listed as marketed; the first generic approval is dated 16 June 2011.
| Generic maker (applicant) | First approval | Products |
|---|---|---|
| Zydus Pharmaceuticals Usa Inc | 16 February 2017 | 1 |
| Sun Pharma Canada Inc | 26 March 2018 | 1 |
| Alembic Pharmaceuticals Ltd | 2 October 2019 | 1 |
Patents and exclusivities still listed
No unexpired patent or exclusivity is listed against the marketed brand products in this group.
Lotion, Topical
Four or more generic makers listed
Brand listed as marketed: Clobex. 4 generic makers with 4 generic products listed as marketed; the first generic approval is dated 4 December 2008.
| Generic maker (applicant) | First approval | Products |
|---|---|---|
| Actavis Mid Atlantic Llc | 4 December 2008 | 1 |
| Sun Pharma Canada Inc | 2 July 2012 | 1 |
| Lupin Ltd | 22 September 2017 | 1 |
| Zydus Lifesciences Ltd | 24 September 2019 | 1 |
Patents and exclusivities still listed
No unexpired patent or exclusivity is listed against the marketed brand products in this group.
Shampoo, Topical
Four or more generic makers listed
Brand listed as marketed: Clobex. 4 generic makers with 4 generic products listed as marketed; the first generic approval is dated 7 June 2011.
| Generic maker (applicant) | First approval | Products |
|---|---|---|
| Padagis Israel Pharmaceuticals Ltd | 9 August 2012 | 1 |
| Alembic Pharmaceuticals Ltd | 18 May 2020 | 1 |
| Sun Pharma Canada Inc | 25 March 2021 | 1 |
| Amneal Pharmaceuticals Llc | 14 June 2021 | 1 |
Patents and exclusivities still listed
No unexpired patent or exclusivity is listed against the marketed brand products in this group.
Gel, Topical
One to three generic makers listed
Every brand product here is listed as discontinued. 3 generic makers with 3 generic products listed as marketed; the first generic approval is dated 31 October 1997.
| Generic maker (applicant) | First approval | Products |
|---|---|---|
| Padagis Us Llc | 31 October 1997 | 1 |
| Sun Pharma Canada Inc | 28 May 1999 | 1 |
| Fougera Pharmaceuticals Inc | 15 February 2000 | 1 |
Patents and exclusivities still listed
No unexpired patent or exclusivity is listed against the marketed brand products in this group.
Suspension/Drops, Ophthalmic
Brand listed, no generic listed as marketed
Brand listed as marketed: Byqlovi. No generic is listed as marketed.
Patents and exclusivities still listed
- 4 March 2027Exclusivity NP Byqlovi
- 9 May 2036Patent 11376262 drug product
- 9 May 2036Patent 10588913 drug product
US Food and Drug Administration, Orange Book data files, downloaded 12 November 2026. A listed patent is not a ruling that a generic is blocked, and no figure here says anything about price, supply or quality. Check the Orange Book.
Where can you go from this result?
Open it in the check to search another medicine, or see every brand with no generic listed. The FDA explains generic approval in how generic drugs are approved and the FDA generic drug facts, and the Orange Book itself is the FDA Orange Book. To check what is available now, ask your pharmacist, and see the FDA drug shortages page.