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OmniRx › Tools › Generic competition check › Bupivacaine

Generic competition · all medicines · read 12 November 2026

Is there a generic of Bupivacaine, and who makes it?

Bupivacaine appears in 2 dosage-form groups in the FDA Orange Book as of 12 November 2026, with no generic maker listed as marketed. 1 group has a brand listed as marketed and no generic listed as marketed. The data does not state why, and it does not state that one is coming. Where both are dated, the first generic approval came 12.7 years after the first brand approval. This is the Orange Book's listing, not a forecast.

Compiled and checked by Vincent Wesley Couey (ORCID 0009-0005-6869-308X) from the Orange Book data files, downloaded 12 November 2026.

Not medical advice. This page reports what the FDA's Orange Book lists, not what a pharmacy has in stock, what anything costs, or whether a generic is right for you. Ask your pharmacist or prescriber about your own medicine.
Bupivacaine2 dosage-form groups in the Orange Book
0generic makers listed
  1. Bupivacaine appears in 2 dosage-form groups in the FDA Orange Book as of 12 November 2026, with no generic maker listed as marketed.
  2. 1 group has a brand listed as marketed and no generic listed as marketed. The data does not state why, and it does not state that one is coming.
  3. Where both are dated, the first generic approval came 12.7 years after the first brand approval.
  4. Patents and exclusivities are shown as listed by the application holder; the Orange Book does not rule on them, and a listed patent is not a statement that a generic is blocked. This says nothing about price, supply or quality.

Injectable, Liposomal, Injection

Brand listed, no generic listed as marketed

Brand listed as marketed: Exparel. No generic is listed as marketed (2 generic products listed as discontinued).

2010201520202025203020352040204501brand 2011data datePatent 11452691 listed to expire 22 January 2041Patent 11819575 listed to expire 22 January 2041Patent 11033495 listed to expire 22 January 2041Patent 12144890 listed to expire 22 January 2041Patent 11179336 listed to expire 22 January 2041Patent 11426348 listed to expire 22 January 2041Patent 12296047 listed to expire 22 January 2041Patent 11357727 listed to expire 22 January 2041Patent 11311486 listed to expire 22 January 2041Patent 11278494 listed to expire 22 January 2041Patent 11304904 listed to expire 22 January 2041Patent 11819574 listed to expire 22 January 2041Patent 11925706 listed to expire 22 January 2041Patent 12151024 listed to expire 22 January 2041Patent 11931459 listed to expire 17 March 2042Patent 12226610 listed to expire 2 February 2043Patent 11918565 listed to expire 2 February 2043Patent 12318483 listed to expire 2 July 2044Patent 12370142 listed to expire 2 July 2044Patent 12251468 listed to expire 2 July 2044Patent 12728094 listed to expire 2 July 2044Patent 12728095 listed to expire 2 July 2044Patent 12156940 listed to expire 2 July 2044
generic makers listed as marketed, by first approvallisted patent expiryexclusivity end

Patents and exclusivities still listed

  • 22 January 2041Patent 11452691 drug product
  • 22 January 2041Patent 11819575 drug product
  • 22 January 2041Patent 11033495 drug product
  • 22 January 2041Patent 12144890 drug product
  • 22 January 2041Patent 11179336 drug product
  • 22 January 2041Patent 11426348 drug product
  • 22 January 2041Patent 12296047 drug product
  • 22 January 2041Patent 11357727 drug product

15 more patents are listed.

Solution, Infiltration

Nothing listed as marketed

Every brand product here is listed as discontinued. No generic is listed as marketed.

20202025203001brand 2021data date
generic makers listed as marketed, by first approvallisted patent expiryexclusivity end

Patents and exclusivities still listed

No unexpired patent or exclusivity is listed against the marketed brand products in this group.

US Food and Drug Administration, Orange Book data files, downloaded 12 November 2026. A listed patent is not a ruling that a generic is blocked, and no figure here says anything about price, supply or quality. Check the Orange Book.

Where can you go from this result?

Open it in the check to search another medicine, or see every brand with no generic listed. The FDA explains generic approval in how generic drugs are approved and the FDA generic drug facts, and the Orange Book itself is the FDA Orange Book. To check what is available now, ask your pharmacist, and see the FDA drug shortages page.