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OmniRx › Tools › Generic competition check › Esketamine Hydrochloride

Generic competition · all medicines · read 12 November 2026

Is there a generic of Esketamine Hydrochloride, and who makes it?

Esketamine Hydrochloride appears in 1 dosage-form group in the FDA Orange Book as of 12 November 2026, with no generic maker listed as marketed. 1 group has a brand listed as marketed and no generic listed as marketed. The data does not state why, and it does not state that one is coming. This is the Orange Book's listing, not a forecast.

Compiled and checked by Vincent Wesley Couey (ORCID 0009-0005-6869-308X) from the Orange Book data files, downloaded 12 November 2026.

Not medical advice. This page reports what the FDA's Orange Book lists, not what a pharmacy has in stock, what anything costs, or whether a generic is right for you. Ask your pharmacist or prescriber about your own medicine.
Esketamine Hydrochloride1 dosage-form group in the Orange Book
0generic makers listed
  1. Esketamine Hydrochloride appears in 1 dosage-form group in the FDA Orange Book as of 12 November 2026, with no generic maker listed as marketed.
  2. 1 group has a brand listed as marketed and no generic listed as marketed. The data does not state why, and it does not state that one is coming.
  3. Patents and exclusivities are shown as listed by the application holder; the Orange Book does not rule on them, and a listed patent is not a statement that a generic is blocked. This says nothing about price, supply or quality.

Spray, Nasal

Brand listed, no generic listed as marketed

Brand listed as marketed: Spravato. No generic is listed as marketed.

20152020202520302035204001brand 2019data datePatent 9592207 listed to expire 20 March 2027Patent 8785500 listed to expire 5 March 2033Patent 11446260 listed to expire 14 March 2034Patent 10869844 listed to expire 10 September 2035Patent 11173134 listed to expire 10 September 2035Patent 11311500 listed to expire 10 September 2035Patent 11883526 listed to expire 18 February 2040Exclusivity I-959 to 17 January 2028
generic makers listed as marketed, by first approvallisted patent expiryexclusivity end

Patents and exclusivities still listed

  • 17 January 2028Exclusivity I-959 Spravato
  • 20 March 2027Patent 9592207
  • 5 March 2033Patent 8785500
  • 14 March 2034Patent 11446260
  • 10 September 2035Patent 10869844
  • 10 September 2035Patent 11173134
  • 10 September 2035Patent 11311500
  • 18 February 2040Patent 11883526

US Food and Drug Administration, Orange Book data files, downloaded 12 November 2026. A listed patent is not a ruling that a generic is blocked, and no figure here says anything about price, supply or quality. Check the Orange Book.

Where can you go from this result?

Open it in the check to search another medicine, or see every brand with no generic listed. The FDA explains generic approval in how generic drugs are approved and the FDA generic drug facts, and the Orange Book itself is the FDA Orange Book. To check what is available now, ask your pharmacist, and see the FDA drug shortages page.