Humira (adalimumab) remains one of the most prescribed biologic medications, but the landscape has shifted dramatically with the arrival of multiple biosimilars in 2023 and 2024. Most insurance plans now prefer biosimilar adalimumab products over brand-name Humira, offering lower copays for biosimilars. Patients on Humira may face step therapy requirements to switch to a biosimilar.

Key Facts

Multiple Humira biosimilars are now available: Hadlima, Hyrimoz, Cyltezo, Amjevita, Yuflyma, and others
Most insurance plans now place biosimilars on a preferred tier with lower copays than brand Humira
AbbVie's Humira copay card may cover the cost difference, keeping patient costs at $5/month
Prior authorization is required for both Humira and its biosimilars on most plans
Without insurance, Humira costs approximately $6,500 to $7,000 per month
Patients stable on Humira may be able to request a formulary exception to avoid switching to a biosimilar

Open Enrollment Reminder

ACA marketplace enrollment runs November 1 to January 15. Medicare Annual Enrollment is October 15 to December 7. Compare formularies for your medications before choosing a plan.

Can't Afford Your Medication?
Find Patient Assistance Programs
Search manufacturer PAPs and nonprofit programs on OmniRx
Compare Cash Prices
Find the Lowest Pharmacy Price
Compare prices at pharmacies near you on RxGrab

Check Your Specific Plan's Formulary

Coverage varies by plan. Use our formulary checker tool to look up your exact copay and restrictions.

Open Formulary Checker

Frequently Asked Questions

Will my insurance make me switch from Humira to a biosimilar?

Many insurance plans are now requiring or incentivizing switches to biosimilar adalimumab products. Some plans have moved brand Humira to a non-preferred tier with higher copays. Your doctor can request a formulary exception if there is a clinical reason to stay on brand Humira. Check with your insurer for your plan's specific policy.

Are Humira biosimilars as effective as Humira?

Yes. FDA-approved biosimilars must demonstrate no clinically meaningful differences from the reference product in terms of safety, purity, and potency. Clinical studies for each biosimilar confirmed equivalent efficacy. The FDA's rigorous approval process ensures biosimilars are safe and effective alternatives.

How much does Humira cost with insurance in 2026?

With insurance, Humira copays range from $5 (with manufacturer copay card) to $500+ per month depending on your plan and tier. Biosimilar copays are typically $0 to $50 on preferred tiers. AbbVie's copay assistance program covers up to $16,000/year in out-of-pocket costs for commercially insured patients.

Related Resources

Get Formulary and Coverage Updates

Subscribe to receive alerts on formulary changes, new drug approvals, and insurance coverage updates.