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What Happens When You Take Lexapro and Wellbutrin Together

Lexapro (escitalopram) and Wellbutrin (bupropion) are sometimes prescribed together intentionally to treat depression that does not respond adequately to either drug alone. This combination is generally well-tolerated, though bupropion can increase escitalopram blood levels and there is a slightly elevated seizure risk.

How This Interaction Works (Mechanism)

Bupropion inhibits CYP2D6, one of the enzymes involved in escitalopram metabolism. This can increase escitalopram plasma concentrations by approximately 30 to 40 percent. Bupropion acts primarily on norepinephrine and dopamine reuptake, while escitalopram targets serotonin, so their therapeutic mechanisms are complementary rather than redundant. The seizure threshold may be slightly lowered by the combination.

Source: American Psychiatric Association Practice Guidelines, 2025

What You Should Do

This combination is commonly used in clinical practice and is generally considered safe under medical supervision. Your doctor may use lower doses of one or both medications. Report any new or worsening side effects, including tremor, restlessness, or seizures. Do not start or stop either medication without consulting your doctor. Avoid alcohol, which can further lower the seizure threshold.

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Frequently Asked Questions

Can I take Lexapro and Wellbutrin together?

Lexapro and Wellbutrin have a mild interaction. In most cases, they can be taken together with appropriate precautions, but you should discuss the combination with your doctor or pharmacist to ensure safety based on your individual health profile.

What are the side effects of the Lexapro and Wellbutrin interaction?

Lexapro (escitalopram) and Wellbutrin (bupropion) are sometimes prescribed together intentionally to treat depression that does not respond adequately to either drug alone. This combination is generally well-tolerated, though bupropion can increase escitalopram blood levels and there is a slightly elevated seizure risk.

Should I talk to my doctor about taking Lexapro and Wellbutrin?

Yes. Anytime you are taking multiple medications, supplements, or substances, you should inform your doctor and pharmacist. They can evaluate your specific risk factors (age, kidney function, other medications, medical conditions) and determine whether the Lexapro and Wellbutrin combination is safe for you, or whether adjustments are needed.

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