Eligibility Requirements
Covered Medications
The following medications are covered by Entresto Savings (via Novartis):
What Makes Entresto Assistance Different
Entresto (sacubitril/valsartan) is a combination angiotensin receptor-neprilysin inhibitor (ARNI) that fundamentally changed the treatment of heart failure with reduced ejection fraction (HFrEF). The landmark PARADIGM-HF clinical trial demonstrated that Entresto reduced cardiovascular death by 20% and heart failure hospitalizations by 21% compared to the previous standard of care, enalapril. Based on these results, Entresto largely replaced ACE inhibitors and ARBs as the cornerstone of HFrEF therapy in major cardiology guidelines. At a retail cost of $600 or more per month ($7,200+ per year), however, many of the 6.7 million Americans living with heart failure struggle to afford it.
The Novartis Patient Assistance Foundation covers Entresto for uninsured patients with household income up to 500% of the Federal Poverty Level, approximately $75,300 for an individual. This threshold is among the most generous for cardiovascular medications. For commercially insured patients, the Entresto savings card can reduce copays to as low as
A few clinical and practical details matter when applying for Entresto assistance. The drug requires dose titration, starting at 24/26 mg twice daily and increasing to the target dose of 97/103 mg twice daily over two to four weeks. Your assistance enrollment covers all dose strengths, so you do not need to reapply when your cardiologist increases your dose. Entresto cannot be taken simultaneously with ACE inhibitors due to serious angioedema risk, and a 36-hour washout period is required when switching from an ACE inhibitor. The Novartis program ships a 90-day supply, but first-time patients may receive a 30-day starter supply during the titration period. If you are a Medicare patient and do not qualify for the PAF, ask your cardiologist about the separate Novartis Medicare assistance track or independent foundations like the PAN Foundation, which periodically opens enrollment for heart failure patients.
How to Apply
- Speak with your healthcare provider about Entresto Savings (via Novartis). Your doctor, nurse, or social worker can help determine if you qualify.
- Gather required documents: proof of income (tax return, pay stubs, or Social Security statement), valid prescription, and proof of U.S. residency.
- Submit your application online or by mail. Visit the program website below or call the program hotline for assistance.
- Wait for approval (typically 2 to 6 weeks). Once approved, medications will be shipped to your provider's office or a designated pharmacy.
Check If You Qualify
Use our free Assistance Finder tool to check eligibility for Entresto Savings (via Novartis) and other programs that may help reduce your medication costs.
Open Assistance FinderFrequently Asked Questions
Uninsured patients with income at or below 400% FPL can receive free Entresto through the Novartis Patient Assistance Foundation. Your cardiologist or prescribing physician must complete the application.
Yes, commercially insured patients may qualify for the Entresto savings card, which can reduce copays to as low as
Yes, Medicare Part D covers Entresto. However, copays can be significant. Medicare patients may qualify for the Novartis Patient Assistance Foundation or independent copay foundations like PAN or HealthWell.
Related Resources
- Compare pharmacy prices for Entresto on RxGrab
- Entresto supplement guide on Health Britannica
- Check drug interactions for Entresto on OmniRx
- Browse all patient assistance programs
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