340B Drug Pricing Program Eligibility Guide (2026)

The following medications are covered by 340B Drug Pricing Program:

The 340B Drug Pricing Program was created by Section 340B of the Public Health Service Act, signed into law in 1992. Unlike manufacturer patient assistance programs, 340B is a federal mandate: drug manufacturers who participate in Medicaid must sell outpatient drugs at steep discounts to eligible healthcare organizations known as "covered entities." These entities include federally qualified health centers (FQHCs), Ryan White HIV/AIDS clinics, STD clinics, hemophilia treatment centers, disproportionate share hospitals (DSH), children's hospitals, and other safety-net providers. The program was designed to stretch limited federal resources and help safety-net providers serve more patients, particularly those who are uninsured or underinsured.

The financial mechanics of 340B differ fundamentally from a traditional PAP. Drug manufacturers must sell covered outpatient drugs at 25% to 50% below average manufacturer price (AMP) to participating entities. These entities then dispense drugs to their patients, often at reduced prices or on sliding-fee scales. Over 50,000 contract pharmacies nationwide participate in the program, meaning you may already be filling prescriptions at a 340B pharmacy without realizing it. The discount is facility-based, not income-based, so there is no FPL threshold for patients. If you receive care at a covered entity, you may benefit regardless of your income level or insurance status. The covered entity decides how to pass savings along, whether through lower drug prices, expanded clinic hours, or additional services.

To benefit from 340B pricing, you must be an established patient of a covered entity. Simply walking into a 340B contract pharmacy without a provider relationship at the covered entity does not qualify you. Start by checking whether your doctor's office, clinic, or hospital is a 340B-registered entity using the HRSA Office of Pharmacy Affairs database at 340bopais.hrsa.gov. Community health centers are the most common access point. If you are currently paying full retail prices at a commercial pharmacy, switching your prescriptions to a 340B contract pharmacy associated with your covered entity could produce immediate savings on every medication you take, not just one specific drug.

1. Speak with your healthcare provider about 340B Drug Pricing Program. Your doctor, nurse, or social worker can help determine if you qualify.
2. Gather required documents: proof of income (tax return, pay stubs, or Social Security statement), valid prescription, and proof of U.S. residency.
3. Submit your application online or by mail. Visit the program website below or call the program hotline for assistance.
4. Wait for approval (typically 2 to 6 weeks). Once approved, medications will be shipped to your provider's office or a designated pharmacy.