Combining Lexapro (escitalopram) with alcohol can increase drowsiness, impair judgment and motor skills, and worsen depression symptoms. Alcohol is a central nervous system depressant that can counteract the therapeutic effects of the antidepressant and increase the risk of dangerous behavior.
How This Interaction Works (Mechanism)
Escitalopram selectively inhibits serotonin reuptake, increasing serotonin availability in the synaptic cleft. Alcohol enhances GABAergic inhibition and suppresses glutamatergic excitation in the brain, producing sedative and depressant effects. The combination amplifies CNS depression, causing greater impairment of cognitive and motor function than either substance alone. Alcohol also disrupts sleep architecture, which can worsen the depression that escitalopram is treating.
Source: Lexapro (Escitalopram) Prescribing Information, Allergan, 2025
The prescribing information for Lexapro recommends avoiding alcohol. If you choose to drink, start with very small amounts to see how the combination affects you. Never drive or operate machinery after drinking while on Lexapro. If you notice worsening depression, increased anxiety, or suicidal thoughts after drinking, contact your doctor immediately.
Check More Drug Interactions
Use our free interaction checker to search thousands of drug, supplement, and food combinations.
Open Interaction CheckerFrequently Asked Questions
Lexapro and Alcohol have a moderate interaction that requires caution. While some patients may take both under medical supervision, the combination can cause adverse effects. Talk to your doctor before combining these medications, and do not adjust doses on your own.
Combining Lexapro (escitalopram) with alcohol can increase drowsiness, impair judgment and motor skills, and worsen depression symptoms. Alcohol is a central nervous system depressant that can counteract the therapeutic effects of the antidepressant and increase the risk of dangerous behavior.
Yes. Anytime you are taking multiple medications, supplements, or substances, you should inform your doctor and pharmacist. They can evaluate your specific risk factors (age, kidney function, other medications, medical conditions) and determine whether the Lexapro and Alcohol combination is safe for you, or whether adjustments are needed.
Related Resources
- Supplement interactions with Lexapro on Health Britannica
- Supplement interactions with Alcohol on Health Britannica
- Lexapro prices and pharmacy comparison on RxGrab
- Alcohol prices and pharmacy comparison on RxGrab
- Full drug interaction checker tool
Get Drug Safety Alerts
Subscribe to receive updates on FDA warnings, new drug interactions, and patient safety information.