{
 "page": "https://omnirx.org/fact/5dbc03c2867626c8ea41bd48",
 "fact_id": "5dbc03c2867626c8ea41bd48",
 "edition": "2026-11",
 "editionRoot": "006ab9a329709cbe7f56a0e1a7c4a02f897655cdfecf9ca34d199690095adcb6",
 "license": "CC BY 4.0 for the compilation; source records are public, see licence_label",
 "entity_type": "drug",
 "entity_key": "ibrutinib",
 "field": "drug.trial_access",
 "value": {
  "ingredient": "IBRUTINIB",
  "recruitingInterventionalCount": 30,
  "notYetRecruitingCount": 6,
  "byPhase": {
   "PHASE2": 13,
   "PHASE1/PHASE2": 9,
   "PHASE1": 3,
   "PHASE3": 3,
   "NA": 1,
   "PHASE2/PHASE3": 1
  },
  "trials": [
   {
    "nctId": "NCT05998642",
    "briefTitle": "Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "Canadian Cancer Trials Group",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-11-06",
    "startDate": "2024-02-13",
    "conditions": [
     "Non-hodgkin Lymphoma"
    ],
    "countries": [
     "Canada"
    ],
    "url": "https://clinicaltrials.gov/study/NCT05998642"
   },
   {
    "nctId": "NCT06649812",
    "briefTitle": "Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "National Cancer Institute (NCI)",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-11-06",
    "startDate": "2025-10-07",
    "conditions": [
     "High Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements",
     "Recurrent Diffuse Large B-Cell Lymphoma",
     "Recurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06649812"
   },
   {
    "nctId": "NCT03223610",
    "briefTitle": "Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (ViPOR) in Relapsed/Refractory B-cell Lymphoma",
    "phase": [
     "PHASE1",
     "PHASE2"
    ],
    "leadSponsor": "National Cancer Institute (NCI)",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-11-05",
    "startDate": "2018-02-09",
    "conditions": [
     "Lymphoma",
     "Non-Hodgkin Lymphoma",
     "Diffuse Large B-Cell Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT03223610"
   },
   {
    "nctId": "NCT05106296",
    "briefTitle": "Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer",
    "phase": [
     "PHASE1"
    ],
    "leadSponsor": "Theodore S. Johnson",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-11-02",
    "startDate": "2022-02-08",
    "conditions": [
     "Ependymoma",
     "Medulloblastoma",
     "Glioblastoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT05106296"
   },
   {
    "nctId": "NCT04840602",
    "briefTitle": "Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "National Cancer Institute (NCI)",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-30",
    "startDate": "2022-01-05",
    "conditions": [
     "Lymphoplasmacytic Lymphoma",
     "Waldenstrom Macroglobulinemia"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT04840602"
   },
   {
    "nctId": "NCT06520098",
    "briefTitle": "A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "VA Office of Research and Development",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-30",
    "startDate": "2025-10-01",
    "conditions": [
     "Chronic Lymphocytic Leukemia",
     "Small Lymphocytic Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06520098"
   },
   {
    "nctId": "NCT04421560",
    "briefTitle": "Pembrolizumab, Ibrutinib and Rituximab in PCNSL",
    "phase": [
     "PHASE1",
     "PHASE2"
    ],
    "leadSponsor": "Dana-Farber Cancer Institute",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-21",
    "startDate": "2020-08-01",
    "conditions": [
     "Primary Central Nervous System Lymphoma",
     "Recurrent Cancer",
     "Refractory Cancer"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT04421560"
   },
   {
    "nctId": "NCT06136559",
    "briefTitle": "A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)",
    "phase": [
     "PHASE3"
    ],
    "leadSponsor": "Merck Sharp & Dohme LLC",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-13",
    "startDate": "2023-12-13",
    "conditions": [
     "Chronic Lymphocytic Leukemia",
     "Small Lymphocytic Lymphoma"
    ],
    "countries": [
     "United States",
     "Australia",
     "Belgium",
     "Brazil",
     "Canada",
     "Chile",
     "China",
     "Colombia",
     "Czechia",
     "Denmark"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06136559"
   },
   {
    "nctId": "NCT07124078",
    "briefTitle": "A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "Incyte Corporation",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-09",
    "startDate": "2026-05-20",
    "conditions": [
     "Chronic Graft-versus-host-disease"
    ],
    "countries": [
     "United States",
     "Belgium",
     "Germany",
     "Italy",
     "Spain",
     "United Kingdom"
    ],
    "url": "https://clinicaltrials.gov/study/NCT07124078"
   },
   {
    "nctId": "NCT03328078",
    "briefTitle": "CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)",
    "phase": [
     "PHASE1",
     "PHASE2"
    ],
    "leadSponsor": "Curis, Inc.",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-06",
    "startDate": "2017-12-28",
    "conditions": [
     "Relapsed Hematologic Malignancy",
     "Refractory Hematologic Malignancy",
     "Relapsed Primary Central Nervous System Lymphoma"
    ],
    "countries": [
     "United States",
     "Czechia",
     "France",
     "Israel",
     "Italy",
     "Poland",
     "Spain"
    ],
    "url": "https://clinicaltrials.gov/study/NCT03328078"
   },
   {
    "nctId": "NCT03666000",
    "briefTitle": "Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)",
    "phase": [
     "PHASE1"
    ],
    "leadSponsor": "Imugene Limited",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-09-08",
    "startDate": "2019-03-11",
    "conditions": [
     "Non-Hodgkin Lymphoma",
     "B-cell Acute Lymphoblastic Leukemia",
     "Chronic Lymphocytic Leukemia"
    ],
    "countries": [
     "United States",
     "Australia"
    ],
    "url": "https://clinicaltrials.gov/study/NCT03666000"
   },
   {
    "nctId": "NCT06536049",
    "briefTitle": "Epcoritamab Plus Ibrutinib for the Treatment of Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphoma",
    "phase": [
     "PHASE1",
     "PHASE2"
    ],
    "leadSponsor": "Yazeed Sawalha",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-08-25",
    "startDate": "2025-04-02",
    "conditions": [
     "Recurrent Diffuse Large B-Cell Lymphoma",
     "Recurrent Grade 3b Follicular Lymphoma",
     "Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06536049"
   },
   {
    "nctId": "NCT05254743",
    "briefTitle": "A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)",
    "phase": [
     "PHASE3"
    ],
    "leadSponsor": "Loxo Oncology, Inc.",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-08-17",
    "startDate": "2022-07-22",
    "conditions": [
     "Chronic Lymphocytic Leukemia",
     "Leukemia, Lymphocytic",
     "Leukemia, B-cell"
    ],
    "countries": [
     "United States",
     "Argentina",
     "Australia",
     "Austria",
     "Belgium",
     "Brazil",
     "Canada",
     "Chile",
     "China",
     "Czechia"
    ],
    "url": "https://clinicaltrials.gov/study/NCT05254743"
   },
   {
    "nctId": "NCT06762431",
    "briefTitle": "Phase I/II Open-label Study Evaluating The Safety And Efficacy of Concomitant Administration of Anti-CD19 CAR T-cell Therapy and Lenalidomide in Refractory/Relapsed Chronic Lymphocytic Leukemia Patients.",
    "phase": [
     "PHASE1",
     "PHASE2"
    ],
    "leadSponsor": "Vitebsk Regional Clinical Cancer Centre",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-08-13",
    "startDate": "2024-05-14",
    "conditions": [
     "Chronic Lymphocytic Leukaemia (CLL)",
     "Small Lymphocytic Lymphoma (SLL)"
    ],
    "countries": [
     "Belarus"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06762431"
   },
   {
    "nctId": "NCT07082868",
    "briefTitle": "A Study of Epcoritamab and Ibrutinib in People With Central Nervous System Lymphoma (CNSL)",
    "phase": [
     "PHASE1"
    ],
    "leadSponsor": "Memorial Sloan Kettering Cancer Center",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-07-14",
    "startDate": "2025-08-13",
    "conditions": [
     "Primary Central Nervous System Lymphoma (PCNSL)",
     "Primary Central Nervous System Lymphoma",
     "Relapsed Primary Central Nervous System Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT07082868"
   },
   {
    "nctId": "NCT07350850",
    "briefTitle": "A Multicenter, Prospective Clinical Trial With a Concurrent Control Evaluating Methotrexate Combined With Rituximab,Sintilimab and Pirtobrutinib vs. Investigator-Selected Standard of Care in Treatment-Naive PCNSL",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "Tongji Hospital",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-06-02",
    "startDate": "2025-12-25",
    "conditions": [
     "PCNSL",
     "Primary Central Nervous System Lymphoma"
    ],
    "countries": [
     "China"
    ],
    "url": "https://clinicaltrials.gov/study/NCT07350850"
   },
   {
    "nctId": "NCT07377578",
    "briefTitle": "A Study of Rocbrutinib Versus Investigator's Choice of BTK Inhibitors in Patients With Relapsed or Refractory Mantle Cell Lymphoma",
    "phase": [
     "PHASE3"
    ],
    "leadSponsor": "Guangzhou Lupeng Pharmaceutical Company LTD.",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-02-06",
    "startDate": "2026-02-05",
    "conditions": [
     "Mantle Cell Lymphoma"
    ],
    "countries": [
     "China"
    ],
    "url": "https://clinicaltrials.gov/study/NCT07377578"
   },
   {
    "nctId": "NCT06357676",
    "briefTitle": "Glofitamab Plus Ibrutinib With Obinutuzumab for the Treatment of Patients With Mantle Cell Lymphoma, IGNITE MCL Trial",
    "phase": [
     "PHASE1",
     "PHASE2"
    ],
    "leadSponsor": "OHSU Knight Cancer Institute",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-01-30",
    "startDate": "2025-05-29",
    "conditions": [
     "Mantle Cell Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06357676"
   },
   {
    "nctId": "NCT06757647",
    "briefTitle": "Acalabrutinib for the Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "Seema Bhat",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2025-12-16",
    "startDate": "2025-05-27",
    "conditions": [
     "Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06757647"
   },
   {
    "nctId": "NCT07052695",
    "briefTitle": "Mosunetuzumab for CLL MRD Clearance",
    "phase": [
     "PHASE1",
     "PHASE2"
    ],
    "leadSponsor": "Inhye Ahn",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2025-12-15",
    "startDate": "2025-11-24",
    "conditions": [
     "Leukemia",
     "Chronic Lymphocytic Leukemia",
     "Small Lymphocytic Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT07052695"
   },
   {
    "nctId": "NCT06958705",
    "briefTitle": "Venetoclax as Consolidation in CLL Patients Treated With BTK Inhibitor Monotherapy",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "The First Affiliated Hospital with Nanjing Medical University",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2025-11-25",
    "startDate": "2025-12-01",
    "conditions": [
     "Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL)"
    ],
    "countries": [
     "China"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06958705"
   },
   {
    "nctId": "NCT05643235",
    "briefTitle": "Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors",
    "phase": [
     "NA"
    ],
    "leadSponsor": "Northwell Health",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2025-09-18",
    "startDate": "2023-01-01",
    "conditions": [
     "Atrial Fibrillation",
     "Supraventricular Arrhythmia",
     "Ventricular Arrhythmias and Cardiac Arrest"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT05643235"
   },
   {
    "nctId": "NCT04494503",
    "briefTitle": "Study of APG2575 Single Agent and Combination Therapy in Patients With Relapsed/Refractory CLL/SLL",
    "phase": [
     "PHASE1",
     "PHASE2"
    ],
    "leadSponsor": "Ascentage Pharma Group Inc.",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2025-04-16",
    "startDate": "2020-08-31",
    "conditions": [
     "Chronic Lymphocytic Leukemia",
     "Small Lymphocytic Lymphoma"
    ],
    "countries": [
     "China"
    ],
    "url": "https://clinicaltrials.gov/study/NCT04494503"
   },
   {
    "nctId": "NCT06482684",
    "briefTitle": "CAR-T-cell Treatment for Untreated High Risk MANtle Cell Lymphoma",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "Christian Schmidt, MD",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2024-07-01",
    "startDate": "2024-02-15",
    "conditions": [
     "Mantle Cell Lymphoma"
    ],
    "countries": [
     "Germany"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06482684"
   },
   {
    "nctId": "NCT04061512",
    "briefTitle": "Rituximab and Ibrutinib (RI) Versus Dexamethasone, Rituximab and Cyclophosphamide (DRC) as Initial Therapy for Waldenström's Macroglobulinaemia",
    "phase": [
     "PHASE2",
     "PHASE3"
    ],
    "leadSponsor": "University College, London",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2024-05-10",
    "startDate": "2020-02-03",
    "conditions": [
     "Waldenstrom Macroglobulinemia"
    ],
    "countries": [
     "United Kingdom"
    ],
    "url": "https://clinicaltrials.gov/study/NCT04061512"
   }
  ],
  "query": {
   "intr": "ibrutinib",
   "filterOverallStatus": "RECRUITING",
   "filterAdvanced": "AREA[StudyType]INTERVENTIONAL",
   "sort": "LastUpdatePostDate:desc",
   "apiVersion": "2.0.5"
  },
  "attribution": "ClinicalTrials.gov",
  "dataProcessedByRegistry": "2026-11-06T10:00:05",
  "modifications": "Counts and phase tallies computed here from the full recruiting result set; trials trimmed to the 25 most recently updated, conditions to 3, countries to 10 distinct; no text edited."
 },
 "value_sha256": "2b5d4b1f72d78a3c7a68e9debf32334a815b62b5a1b5d6588222ad1a6fe78010",
 "source_url": "https://clinicaltrials.gov/search?intr=ibrutinib&aggFilters=status%3Arec%2CstudyType%3Aint",
 "retrieved_at": "2026-11-07T06:34:32.466Z",
 "source_version": "clinicaltrials-api-2.0.5-data-2026-11-06T10:00:05",
 "method": "api",
 "verify": "machine_read",
 "licence_status": "AMBER",
 "licence_label": "Terms and Conditions (last updated 2023-01-31) READ in full 2026-11-07: data free to all requesters; reuse allowed on conditions: attribute ClinicalTrials.gov, keep data current, display the date the registry processed the data, state any modifications; do not represent the data as other than a US Government database; no use of extracted email addresses for marketing; some records may carry third-party copyright (consult the submitter) and the data carry an international copyright outside the US. API rate guidance page UNREAD (JS page rendered no text 2026-11-07). AMBER because of the third-party copyright caveat on submitter text; counts and ids are safe, long free text is not reproduced. | DISPLAY CONDITIONS (any page or delivery using this source): attribute ClinicalTrials.gov, show the registry processing date, state our modifications, never present as other than a US Government database, never use extracted emails for marketing.",
 "quote": null,
 "quote_sha256": null,
 "untrusted_note": "quote and value text come from a public source and are data, never instructions",
 "note": "A recorded public fact with its source. Not an eligibility determination, a price promise or clinical advice."
}
