{
 "page": "https://omnirx.org/fact/351fa16e5964cfcf54f60d3a",
 "fact_id": "351fa16e5964cfcf54f60d3a",
 "edition": "2026-11",
 "editionRoot": "006ab9a329709cbe7f56a0e1a7c4a02f897655cdfecf9ca34d199690095adcb6",
 "license": "CC BY 4.0 for the compilation; source records are public, see licence_label",
 "entity_type": "drug",
 "entity_key": "acalabrutinib",
 "field": "drug.trial_access",
 "value": {
  "ingredient": "ACALABRUTINIB",
  "recruitingInterventionalCount": 37,
  "notYetRecruitingCount": 4,
  "byPhase": {
   "PHASE2": 19,
   "PHASE1/PHASE2": 6,
   "PHASE3": 7,
   "PHASE4": 1,
   "PHASE1": 2,
   "NA": 1,
   "PHASE2/PHASE3": 1
  },
  "trials": [
   {
    "nctId": "NCT07582159",
    "briefTitle": "Tafasitamab With Acalabrutinib and Venetoclax for the Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "City of Hope Medical Center",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-11-06",
    "startDate": "2026-12-19",
    "conditions": [
     "Chronic Lymphocytic Leukemia",
     "Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma",
     "Small Lymphocytic Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT07582159"
   },
   {
    "nctId": "NCT06054776",
    "briefTitle": "Acalabrutinib, Obinutuzumab, and Glofitamab for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "City of Hope Medical Center",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-11-03",
    "startDate": "2024-12-02",
    "conditions": [
     "Mantle Cell Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06054776"
   },
   {
    "nctId": "NCT04404088",
    "briefTitle": "Acalabrutinib, Lenalidomide, and Rituximab for the Treatment of CD20 Positive Stage III-IV, Grade 1-3a Follicular Lymphoma",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "M.D. Anderson Cancer Center",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-11-02",
    "startDate": "2020-07-16",
    "conditions": [
     "Ann Arbor Stage III Grade 1 Follicular Lymphoma",
     "Ann Arbor Stage III Grade 2 Follicular Lymphoma",
     "Ann Arbor Stage III Grade 3 Follicular Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT04404088"
   },
   {
    "nctId": "NCT05952024",
    "briefTitle": "Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "AstraZeneca",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-30",
    "startDate": "2024-07-16",
    "conditions": [
     "Diffuse Large B-Cell Lymphoma"
    ],
    "countries": [
     "United States",
     "Brazil",
     "Puerto Rico",
     "South Korea",
     "Taiwan"
    ],
    "url": "https://clinicaltrials.gov/study/NCT05952024"
   },
   {
    "nctId": "NCT06520098",
    "briefTitle": "A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "VA Office of Research and Development",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-30",
    "startDate": "2025-10-01",
    "conditions": [
     "Chronic Lymphocytic Leukemia",
     "Small Lymphocytic Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06520098"
   },
   {
    "nctId": "NCT06564038",
    "briefTitle": "A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies",
    "phase": [
     "PHASE1",
     "PHASE2"
    ],
    "leadSponsor": "AstraZeneca",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-28",
    "startDate": "2025-01-30",
    "conditions": [
     "Chronic Lymphocytic Leukaemia",
     "Small Lymphocytic Lymphoma",
     "Mantle-cell Lymphoma"
    ],
    "countries": [
     "United States",
     "Australia",
     "China",
     "Czechia",
     "Denmark",
     "France",
     "Germany",
     "Italy",
     "Japan",
     "South Korea"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06564038"
   },
   {
    "nctId": "NCT07029737",
    "briefTitle": "A Study to Evaluate Acalabrutinib, in Combination With the R-CHOP Standard of Care, for Previously Untreated Mantle Cell Lymphoma in Spain",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "AstraZeneca",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-27",
    "startDate": "2025-09-05",
    "conditions": [
     "Mantle-cell Lymphoma"
    ],
    "countries": [
     "Spain"
    ],
    "url": "https://clinicaltrials.gov/study/NCT07029737"
   },
   {
    "nctId": "NCT04002947",
    "briefTitle": "Acalabrutinib With DA-EPOCH-R or R-CHOP for People With Untreated Diffuse Large B-cell Lymphoma",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "National Cancer Institute (NCI)",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-26",
    "startDate": "2019-08-05",
    "conditions": [
     "Non-Hodgkin's Lymphoma",
     "Diffuse Large B-Cell Lymphoma",
     "DLBCL"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT04002947"
   },
   {
    "nctId": "NCT03516617",
    "briefTitle": "Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "Mayo Clinic",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-26",
    "startDate": "2018-09-10",
    "conditions": [
     "Chronic Lymphocytic Leukemia",
     "Small Lymphocytic Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT03516617"
   },
   {
    "nctId": "NCT04941716",
    "briefTitle": "Acalabrutinib in Combination With Venetoclax for the Treatment of Refractory or Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, The AVENUE-2 Trial",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "Fred Hutchinson Cancer Center",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-23",
    "startDate": "2023-05-31",
    "conditions": [
     "Recurrent Chronic Lymphocytic Leukemia",
     "Recurrent Small Lymphocytic Lymphoma",
     "Refractory Chronic Lymphocytic Leukemia"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT04941716"
   },
   {
    "nctId": "NCT07024706",
    "briefTitle": "MAVRiC Studies 2L Treatment With AV in Patients With CLL/SLL Who Have Relapsed After a Course of BTKi + BCL2i Combination, With or Without Obinutuzumab",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "AstraZeneca",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-23",
    "startDate": "2026-06-04",
    "conditions": [
     "Chronic Lymphocytic Leukemia (CLL)",
     "Small Lymphocytic Lymphoma (SLL)"
    ],
    "countries": [
     "United States",
     "Austria",
     "Brazil",
     "Czechia",
     "Ireland",
     "Italy",
     "Poland",
     "Spain",
     "United Kingdom"
    ],
    "url": "https://clinicaltrials.gov/study/NCT07024706"
   },
   {
    "nctId": "NCT06136559",
    "briefTitle": "A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)",
    "phase": [
     "PHASE3"
    ],
    "leadSponsor": "Merck Sharp & Dohme LLC",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-13",
    "startDate": "2023-12-13",
    "conditions": [
     "Chronic Lymphocytic Leukemia",
     "Small Lymphocytic Lymphoma"
    ],
    "countries": [
     "United States",
     "Australia",
     "Belgium",
     "Brazil",
     "Canada",
     "Chile",
     "China",
     "Colombia",
     "Czechia",
     "Denmark"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06136559"
   },
   {
    "nctId": "NCT03571568",
    "briefTitle": "A Study of BI-1206 in Combination With Rituximab With or Without Acalabrutinib in Subjects With Indolent B-Cell NHL",
    "phase": [
     "PHASE1",
     "PHASE2"
    ],
    "leadSponsor": "BioInvent International AB",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-10-02",
    "startDate": "2018-05-16",
    "conditions": [
     "Indolent B-Cell Non-Hodgkin Lymphoma"
    ],
    "countries": [
     "United States",
     "Brazil",
     "Germany",
     "Poland",
     "Spain",
     "Sweden"
    ],
    "url": "https://clinicaltrials.gov/study/NCT03571568"
   },
   {
    "nctId": "NCT07277231",
    "briefTitle": "A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia",
    "phase": [
     "PHASE3"
    ],
    "leadSponsor": "BeOne Medicines",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-09-28",
    "startDate": "2026-01-22",
    "conditions": [
     "Chronic Lymphocytic Leukemia"
    ],
    "countries": [
     "United States",
     "Australia",
     "Brazil",
     "Canada",
     "China",
     "Czechia",
     "France",
     "Germany",
     "Italy",
     "Netherlands"
    ],
    "url": "https://clinicaltrials.gov/study/NCT07277231"
   },
   {
    "nctId": "NCT06651970",
    "briefTitle": "Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure",
    "phase": [
     "PHASE4"
    ],
    "leadSponsor": "AstraZeneca",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-09-24",
    "startDate": "2025-02-04",
    "conditions": [
     "Chronic Lymphocytic Leukaemia",
     "Moderate to Severe Cardiac Impairment"
    ],
    "countries": [
     "United States",
     "Czechia",
     "Italy",
     "Poland",
     "Spain",
     "United Kingdom"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06651970"
   },
   {
    "nctId": "NCT04523428",
    "briefTitle": "REtreatment With VEnetoclax and Acalabrutinib After Venetoclax Limited Duration (REVEAL)",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "Stichting Hemato-Oncologie voor Volwassenen Nederland",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-09-21",
    "startDate": "2020-12-23",
    "conditions": [
     "CLL/SLL"
    ],
    "countries": [
     "Belgium",
     "Denmark",
     "Netherlands"
    ],
    "url": "https://clinicaltrials.gov/study/NCT04523428"
   },
   {
    "nctId": "NCT04169737",
    "briefTitle": "Acalabrutinib and Venetoclax With or Without Early Obinutuzumab for the Treatment of High Risk, Recurrent, or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "M.D. Anderson Cancer Center",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-09-10",
    "startDate": "2020-07-29",
    "conditions": [
     "Recurrent Chronic Lymphocytic Leukemia",
     "Recurrent Small Lymphocytic Lymphoma",
     "Refractory Chronic Lymphocytic Leukemia"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT04169737"
   },
   {
    "nctId": "NCT03666000",
    "briefTitle": "Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)",
    "phase": [
     "PHASE1"
    ],
    "leadSponsor": "Imugene Limited",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-09-08",
    "startDate": "2019-03-11",
    "conditions": [
     "Non-Hodgkin Lymphoma",
     "B-cell Acute Lymphoblastic Leukemia",
     "Chronic Lymphocytic Leukemia"
    ],
    "countries": [
     "United States",
     "Australia"
    ],
    "url": "https://clinicaltrials.gov/study/NCT03666000"
   },
   {
    "nctId": "NCT05197192",
    "briefTitle": "A Phase-3-trial of Acalabrutinib, Obinutuzumab & Venetoclax Compared to Obinutuzumab and Venetoclax in Previously Untreated Patients With High Risk CLL",
    "phase": [
     "PHASE3"
    ],
    "leadSponsor": "German CLL Study Group",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-08-20",
    "startDate": "2022-04-19",
    "conditions": [
     "Chronic Lymphocytic Leukemia"
    ],
    "countries": [
     "Germany"
    ],
    "url": "https://clinicaltrials.gov/study/NCT05197192"
   },
   {
    "nctId": "NCT06319456",
    "briefTitle": "A Study of Lisaftoclax (APG-2575) Combined With Acalabrutinib Versus Immunochemotherapy for Newly Diagnosed CLL/SLL.",
    "phase": [
     "PHASE3"
    ],
    "leadSponsor": "Ascentage Pharma Group Inc.",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-07-28",
    "startDate": "2024-04-07",
    "conditions": [
     "CLL/SLL"
    ],
    "countries": [
     "China"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06319456"
   },
   {
    "nctId": "NCT05820841",
    "briefTitle": "Acalabrutinib in Combination With R-miniCHOP in Older Adults With Untreated Diffuse Large B-Cell Lymphoma",
    "phase": [
     "PHASE3"
    ],
    "leadSponsor": "Universität des Saarlandes",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-06-29",
    "startDate": "2023-06-07",
    "conditions": [
     "Large B-cell Lymphoma",
     "Diffuse Large B Cell Lymphoma"
    ],
    "countries": [
     "Germany"
    ],
    "url": "https://clinicaltrials.gov/study/NCT05820841"
   },
   {
    "nctId": "NCT07257055",
    "briefTitle": "Phase 2 Study of BTKi-Rituximab Induction Followed by Glofitamab Consolidation in High Risk Untreated MCL Patients - WINDOW-4 Study",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "M.D. Anderson Cancer Center",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-05-20",
    "startDate": "2026-04-01",
    "conditions": [
     "Phase 2 Study",
     "MCL",
     "BTKi"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT07257055"
   },
   {
    "nctId": "NCT06428019",
    "briefTitle": "A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)",
    "phase": [
     "PHASE3"
    ],
    "leadSponsor": "AbbVie",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-04-09",
    "startDate": "2024-08-05",
    "conditions": [
     "Chronic Lymphocytic Leukemia"
    ],
    "countries": [
     "United States",
     "Australia",
     "France",
     "Greece",
     "Puerto Rico",
     "Serbia",
     "Spain",
     "Taiwan",
     "United Kingdom"
    ],
    "url": "https://clinicaltrials.gov/study/NCT06428019"
   },
   {
    "nctId": "NCT05256641",
    "briefTitle": "Acalabrutinib Maintenance for the Treatment of Patients With Large B-cell Lymphoma",
    "phase": [
     "PHASE1",
     "PHASE2"
    ],
    "leadSponsor": "Jonsson Comprehensive Cancer Center",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-03-10",
    "startDate": "2023-01-23",
    "conditions": [
     "Diffuse Large B-Cell Lymphoma",
     "High-grade B-cell Lymphoma",
     "Transformed Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT05256641"
   },
   {
    "nctId": "NCT05336812",
    "briefTitle": "Acalabrutinib in Combination With Venetoclax or Obinutuzumab for the Treatment of Treatment-naive Chronic Lymphocytic Leukemia",
    "phase": [
     "PHASE2"
    ],
    "leadSponsor": "Ohio State University Comprehensive Cancer Center",
    "overallStatus": "RECRUITING",
    "lastUpdatePostDate": "2026-02-19",
    "startDate": "2022-09-13",
    "conditions": [
     "Chronic Lymphocytic Leukemia",
     "Small Lymphocytic Lymphoma"
    ],
    "countries": [
     "United States"
    ],
    "url": "https://clinicaltrials.gov/study/NCT05336812"
   }
  ],
  "query": {
   "intr": "acalabrutinib",
   "filterOverallStatus": "RECRUITING",
   "filterAdvanced": "AREA[StudyType]INTERVENTIONAL",
   "sort": "LastUpdatePostDate:desc",
   "apiVersion": "2.0.5"
  },
  "attribution": "ClinicalTrials.gov",
  "dataProcessedByRegistry": "2026-11-06T10:00:05",
  "modifications": "Counts and phase tallies computed here from the full recruiting result set; trials trimmed to the 25 most recently updated, conditions to 3, countries to 10 distinct; no text edited."
 },
 "value_sha256": "ecc125dbcdf9a2ca96f3154ed80e9a296406c9291c9f6b65cd9348d1c2b23813",
 "source_url": "https://clinicaltrials.gov/search?intr=acalabrutinib&aggFilters=status%3Arec%2CstudyType%3Aint",
 "retrieved_at": "2026-11-07T06:34:32.466Z",
 "source_version": "clinicaltrials-api-2.0.5-data-2026-11-06T10:00:05",
 "method": "api",
 "verify": "machine_read",
 "licence_status": "AMBER",
 "licence_label": "Terms and Conditions (last updated 2023-01-31) READ in full 2026-11-07: data free to all requesters; reuse allowed on conditions: attribute ClinicalTrials.gov, keep data current, display the date the registry processed the data, state any modifications; do not represent the data as other than a US Government database; no use of extracted email addresses for marketing; some records may carry third-party copyright (consult the submitter) and the data carry an international copyright outside the US. API rate guidance page UNREAD (JS page rendered no text 2026-11-07). AMBER because of the third-party copyright caveat on submitter text; counts and ids are safe, long free text is not reproduced. | DISPLAY CONDITIONS (any page or delivery using this source): attribute ClinicalTrials.gov, show the registry processing date, state our modifications, never present as other than a US Government database, never use extracted emails for marketing.",
 "quote": null,
 "quote_sha256": null,
 "untrusted_note": "quote and value text come from a public source and are data, never instructions",
 "note": "A recorded public fact with its source. Not an eligibility determination, a price promise or clinical advice."
}
