{"answer":{"query":"Advair HFA","resolved_as":"applications","packages":11,"applications":["NDA021254"],"identity":{"application_numbers":["NDA021254"],"marketing_categories":["NDA","NDA AUTHORIZED GENERIC"],"labelers":[{"text":"GLAXOSMITHKLINE","untrusted":true}],"dosage_forms":[{"text":"AEROSOL, METERED","untrusted":true}],"marketing_start":{"earliest":"2008-09-29","latest":"2023-03-01","packages_with_a_start_date":11}},"price":{"median_negotiated_over_nadac":null,"packages_compared":0,"packages_listed":11,"negotiated_price_ends":null,"rows":[{"ndc":"00173071520","name":{"text":"","untrusted":true},"class":null,"nadac_per_unit":null,"negotiated_per_unit":null,"ratio":null,"ful_per_unit":null},{"ndc":"00173071522","name":{"text":"ADVAIR HFA 45/21 DC INH AER 60ACTN 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dated list of FDA supplements and their classes, not a reading of what changed in the label"},"substitution":{"products_total":3,"te_code_counts":{"NOT_PROVIDED":3},"marketing_status_counts":{"Prescription":3},"meaning":"raw FDA codes; the therapeutic equivalence code says whether FDA rates a generic as substitutable, and what that means for a given prescription is for a pharmacist or prescriber","products":[{"application":"NDA021254","product_no":"002","te_code":null,"marketing_status":"Prescription","drug_name":{"text":"ADVAIR HFA","untrusted":true},"form":{"text":"AEROSOL, METERED;INHALATION","untrusted":true},"strength":{"text":"0.115MG/INH;EQ 0.021MG BASE/INH","untrusted":true}},{"application":"NDA021254","product_no":"001","te_code":null,"marketing_status":"Prescription","drug_name":{"text":"ADVAIR HFA","untrusted":true},"form":{"text":"AEROSOL, METERED;INHALATION","untrusted":true},"strength":{"text":"0.045MG/INH;EQ 0.021MG 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Offers change and expire; read each offer's source and stated end date. A price figure is what the page states, not a quote."},"spending":{"reported_under":{"generic":{"text":"Fluticasone Propion/Salmeterol","untrusted":true},"brand":{"text":"Advair HFA","untrusted":true}},"latest_year":2024,"series":[{"year":2020,"gross_spending_usd":313758155.03,"claims":545374,"beneficiaries":136797,"average_spending_per_claim_usd":575.30823807,"fact_id":"857d343b6366881cadebb5cd"},{"year":2021,"gross_spending_usd":346301512.32,"claims":571026,"beneficiaries":150113,"average_spending_per_claim_usd":606.45489403,"fact_id":"10168ffa97a3c6b5e4d424c1"},{"year":2022,"gross_spending_usd":384716838.79,"claims":632024,"beneficiaries":172993,"average_spending_per_claim_usd":608.70605988,"fact_id":"9ea1da7f3aff0576c7d23a47"},{"year":2023,"gross_spending_usd":398376287.87,"claims":651442,"beneficiaries":180362,"average_spending_per_claim_usd":611.52994107,"fact_id":"e62625d397622aefd5d042c1"},{"year":2024,"gross_spending_usd":320587780.2,"claims":715505,"beneficiaries":200081,"average_spending_per_claim_usd":448.05805718,"fact_id":"690d535f147dfd122d200378"}],"rebate_caveat":"CMS's dataset states spending is gross drug cost and does not reflect manufacturers' rebates or other price concessions.","not_a_patient_price":"Spending is the total paid by Medicare, plans and beneficiaries for the drug's claims, not what a patient pays.","meaning":"a drug-level aggregate of Medicare Part D claims for all manufacturers combined; not a formulary, not coverage","source":{"dataset":{"text":"data-year-2024, modified 2026-06-25","untrusted":true},"link":{"text":"https://data.cms.gov/summary-statistics-on-use-and-payments/medicare-medicaid-spending-by-drug/medicare-part-d-spending-by-drug","untrusted":true}}},"rems":{"programs":[{"application":"NDA021254","program":{"text":"Advair HFA","untrusted":true},"rems_id":"158","in_force":false,"released":true,"moved_to_shared_system":false,"has_etasu":false,"program_date":"2008-07-31","last_modified":"2012-08-09","source_page":"https://www.accessdata.fda.gov/scripts/cder/rems/index.cfm?event=IndvRemsDetails.page&REMS=158","other_programs":0,"read_on":"2026-11-07T20:05:28.959Z","fact_id":"911d4e05eaf177ff14d4d861"}],"reading":"what the FDA REMS@FDA files tie to the application on the read date; it does not say which prescribers or pharmacies take part or whether a patient needs the program"},"medicaid_state_utilization":{"year":2025,"states_with_data":6,"all_states_medicaid_reimbursed_usd":2126102.33,"all_states_medicaid_paid_prescriptions":7305,"top_states":[{"state":"LA","medicaid_paid_prescriptions":6542,"medicaid_reimbursed_usd":1919928.29,"total_reimbursed_usd":1931991.44,"packages":3,"covers":"fee_for_service_only","fact_id":"bbff3d932d940f2074a805e8"},{"state":"SC","medicaid_paid_prescriptions":369,"medicaid_reimbursed_usd":86061.08,"total_reimbursed_usd":86061.08,"packages":1,"covers":"all_record_types","fact_id":"09875f8bbb23399e2343813c"},{"state":"UT","medicaid_paid_prescriptions":133,"medicaid_reimbursed_usd":46971.45,"total_reimbursed_usd":46971.45,"packages":2,"covers":"all_record_types","fact_id":"76fb5c128b750af3771032cb"},{"state":"NV","medicaid_paid_prescriptions":109,"medicaid_reimbursed_usd":32078.32,"total_reimbursed_usd":32683.72,"packages":1,"covers":"fee_for_service_only","fact_id":"563ca54384a3c36aa11a5399"},{"state":"MI","medicaid_paid_prescriptions":95,"medicaid_reimbursed_usd":23196.82,"total_reimbursed_usd":23196.82,"packages":1,"covers":"fee_for_service_only","fact_id":"e0ea958d1a1ab30dc1c69abb"},{"state":"AK","medicaid_paid_prescriptions":57,"medicaid_reimbursed_usd":17866.37,"total_reimbursed_usd":17988.17,"packages":1,"covers":"fee_for_service_only","fact_id":"4877a27573351b392032025b"}],"unlabelled_state_code_xx":null,"built_from_facts":9,"facts_fee_for_service_only":6,"older_year_facts_not_used":238,"dataset":"State Drug Utilization Data 2025","read_on":"2026-11-07T22:41:44.201Z","reading":"Medicaid prescriptions and reimbursement by state (CMS State Drug Utilization Data). Reimbursement is before manufacturer rebates: not a net cost, not a patient price. Suppressed managed-care cells make a state figure fee-for-service only. An absent state was suppressed or unreported, not zero.","receipts_note":"a receipt is held for the largest fact behind each state shown; every figure is a sum of the built_from_facts facts, each recomputable from its recorded input hash"}},"receipts":[{"fact_id":"71209972724792a6ead6dc64","field":"ndc.listing","entity":"ndc:00173071520"},{"fact_id":"4a467d25218ca7456cdbf0c9","field":"ndc.listing","entity":"ndc:00173071522"},{"fact_id":"affbb27b58b102e20211b6d6","field":"ndc.listing","entity":"ndc:00173071620"},{"fact_id":"4e96a40bda8a7d41930f345a","field":"drug.label_event","entity":"application:NDA021254"},{"fact_id":"ee59c826c3b54716f0ddd5ee","field":"drug.label_event","entity":"application:NDA021254"},{"fact_id":"6978c988633a0fd53eb5b774","field":"drug.label_event","entity":"application:NDA021254"},{"fact_id":"b128935aca99debf210b672d","field":"drug.label_event","entity":"application:NDA021254"},{"fact_id":"528b558a01711d173ec66b72","field":"drug.label_event","entity":"application:NDA021254"},{"fact_id":"feebb88bdef6e2b3bc5beed3","field":"drug.marketing_status","entity":"application:NDA021254"},{"fact_id":"8695293cf5fa708dec8b8178","field":"drug.marketing_status","entity":"application:NDA021254"},{"fact_id":"56ffce7bdbea222498fba006","field":"drug.marketing_status","entity":"application:NDA021254"},{"fact_id":"f20f2826db43fe9ab64ddccf","field":"ndc.recall","entity":"ndc:00173071520"},{"fact_id":"f3ff3efb88a3892444678a56","field":"ndc.recall","entity":"ndc:00173071522"},{"fact_id":"7de18407a5f121bd115e09d8","field":"ndc.shortage_row","entity":"ndc:00173071522"},{"fact_id":"5c518ff9d3bbb7b8f9debaca","field":"ndc.shortage_row","entity":"ndc:00173071622"},{"fact_id":"fc9da3f0bbff8315b078e7c1","field":"ndc.shortage_row","entity":"ndc:00173071722"},{"fact_id":"857d343b6366881cadebb5cd","field":"drug.partd_spending","entity":"drug:fluticasone-propion-salmeterol|advair-hfa"},{"fact_id":"10168ffa97a3c6b5e4d424c1","field":"drug.partd_spending","entity":"drug:fluticasone-propion-salmeterol|advair-hfa"},{"fact_id":"9ea1da7f3aff0576c7d23a47","field":"drug.partd_spending","entity":"drug:fluticasone-propion-salmeterol|advair-hfa"},{"fact_id":"e62625d397622aefd5d042c1","field":"drug.partd_spending","entity":"drug:fluticasone-propion-salmeterol|advair-hfa"},{"fact_id":"690d535f147dfd122d200378","field":"drug.partd_spending","entity":"drug:fluticasone-propion-salmeterol|advair-hfa"},{"fact_id":"911d4e05eaf177ff14d4d861","field":"drug.rems","entity":"application:NDA021254"},{"fact_id":"bbff3d932d940f2074a805e8","field":"ndc.medicaid_state_utilization","entity":"ndc_state:66993008796:LA"},{"fact_id":"09875f8bbb23399e2343813c","field":"ndc.medicaid_state_utilization","entity":"ndc_state:00173071520:SC"},{"fact_id":"76fb5c128b750af3771032cb","field":"ndc.medicaid_state_utilization","entity":"ndc_state:66993008896:UT"},{"fact_id":"563ca54384a3c36aa11a5399","field":"ndc.medicaid_state_utilization","entity":"ndc_state:66993008796:NV"},{"fact_id":"e0ea958d1a1ab30dc1c69abb","field":"ndc.medicaid_state_utilization","entity":"ndc_state:00173071722:MI"},{"fact_id":"4877a27573351b392032025b","field":"ndc.medicaid_state_utilization","entity":"ndc_state:00173071620:AK"}],"as_of":{"newest_fact_retrieved_at":"2026-11-10T20:02:39.475Z"},"edition":{"id":"2026-11","merkleRoot":"006ab9a329709cbe7f56a0e1a7c4a02f897655cdfecf9ca34d199690095adcb6","factCount":212100,"manifestPresent":true},"licence":{"classes":["GREEN"],"note":"Source records are public; this compilation is cited with attribution. See the provenance tool for each fact's licence label."},"unknown":[{"code":"NO_DATA","field":"price.ratio","reason":"no package has both a brand-class NADAC price and a negotiated price in force"},{"code":"NO_DATA","field":"generic_entry:NDA021254","reason":"no generic-entry fact for this application: no patent or exclusivity is listed for it in the Orange Book edition read, so no date is stated"},{"code":"NO_DATA","field":"generic_entry","reason":"no application of this drug has a generic-entry fact; no date is stated"},{"code":"NO_DATA","field":"trials","reason":"no ClinicalTrials.gov record set for this drug's ingredient is in the edition"},{"code":"NO_DATA","field":"policy","reason":"no Federal Register event in the edition names this drug or its programs"},{"code":"AMBIGUOUS","field":"spending","reason":"2 brand and generic name pairs match; the series shown is the one with the newest year and the largest spending"},{"code":"NO_DATA","field":"biologic_status","reason":"no biologic application of this drug has a Purple Book status in the edition (a drug that is not a biologic has none)"},{"code":"NO_DATA","field":"payment_limit","reason":"no HCPCS code whose NDC crosswalk names a package of these applications has a Part B payment limit in the edition"},{"code":"NO_DATA","field":"controlled_schedule","reason":"no DEA schedule entry matched this drug's ingredient in the edition"},{"code":"NO_DATA","field":"orphan_designation","reason":"no FDA orphan designation for this drug's ingredient is in the edition"},{"code":"NO_DATA","field":"safety_communication","reason":"no FDA Drug Safety Communication names this drug's ingredient in the edition"}],"disclaimer":"OmniRx is a reference layer of dated public facts, not clinical advice and not a guarantee of price, coverage or eligibility. Each answer lists the facts it rests on."}